Protein Info for MMP_RS05890 in Methanococcus maripaludis S2

Annotation: ATP-dependent helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 855 PF00270: DEAD" amino acids 16 to 200 (185 residues), 108.8 bits, see alignment E=6.2e-35 PF04851: ResIII" amino acids 30 to 200 (171 residues), 33.3 bits, see alignment E=1.2e-11 PF00271: Helicase_C" amino acids 256 to 364 (109 residues), 63.2 bits, see alignment E=6.6e-21 PF19306: WH_Lhr" amino acids 395 to 558 (164 residues), 99.9 bits, see alignment E=2.7e-32 PF08494: DEAD_assoc" amino acids 628 to 813 (186 residues), 169.5 bits, see alignment E=2e-53

Best Hits

KEGG orthology group: K03724, ATP-dependent helicase Lhr and Lhr-like helicase [EC: 3.6.4.-] (inferred from 100% identity to mmp:MMP1141)

Predicted SEED Role

"FIG003033: Helicase domain protein"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY51 at UniProt or InterPro

Protein Sequence (855 amino acids)

>MMP_RS05890 ATP-dependent helicase (Methanococcus maripaludis S2)
LNKFEPYKSINNGYFTPPQRLAIPKIHFGRNTLICSPTGSGKTLSSFIAIINELFRIEKE
EGLQNSIYCLYISPLKSLANDIHVNLDEPLTEIKEILKEEGNEITGIRHAIRHGDTSNYE
KSKMLKKTPHILNTTPETLAIILNSPKFKEKLKTVQWVIIDEIHALADNKRGVHLSISLE
RLRELTNQEFLRIGCSATVEPLEMVADYLGGYYDDGYKRPVEIVDTRFVRGYDLKLLCPV
DDLINKTPKEISEKLYEKLDRLIQTHENTLIFTNTRGGAERVLYNLRKRYPEKYDETNSG
CHHGSLSKEKRLELEEKLKSGNLKFATTSSSLELGIDMPYIDLVVQIGSPKSVKTMLQRI
GRAGHGIGKVAKGRIIALDRDELLECAVMLKKAMDGFIDKVHIPKGPLDVLIQHIYGIAI
NGYIELERVKNIVRRSYNYHDITDEDFKILINYMTASYAGMDEKRIYSKIWYDPDTQMIG
KTGKTARAIYYMNIGTIPDDFSCDVYLRGTTIWIGKLDEQYLDRLEKGDVFTLGGEHLKF
QYRRGSKVYVDKTSERPNIPSWYSERLPLSYDLGRNILLFKKEAVSKYNAGRLLDLLSEY
PLDSNATKSLYGLFNEQILYKGNDSVSTLNKMVVEGHIFDKKMHYYFHSNYGRKFNDGFS
RAVAYALSKQYKLGVLVSISDTGFSLEFAKNQKVDIESAIRSLTPENIKDVLKQALEGTN
LLKRMFRINATRSLMILRNYIGHKKSAKKQQVSADILISYAKSLDRFAPLEETLREIIED
SLELDNIREVLGEIRSGKLKINVIDVPIPTPMSFGIATLTASDSVLAENKNQLLKEFHQM
VIKMIEYEKGISLEE