Protein Info for MMP_RS05855 in Methanococcus maripaludis S2

Annotation: FprA family A-type flavoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 407 PF19583: ODP" amino acids 35 to 235 (201 residues), 48.4 bits, see alignment E=1.6e-16 PF00753: Lactamase_B" amino acids 35 to 182 (148 residues), 43.3 bits, see alignment E=6.3e-15 PF00258: Flavodoxin_1" amino acids 262 to 395 (134 residues), 58.9 bits, see alignment E=1e-19

Best Hits

Swiss-Prot: 81% identical to FPRA_METJA: Type A flavoprotein FprA (fprA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1134)

MetaCyc: 65% identical to coenzyme F420H2 oxidase subunit (Methanothermobacter marburgensis Marburg)
RXN-14991 [EC: 1.5.3.22]

Predicted SEED Role

"F420H2 oxidase (FprA)"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.3.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY57 at UniProt or InterPro

Protein Sequence (407 amino acids)

>MMP_RS05855 FprA family A-type flavoprotein (Methanococcus maripaludis S2)
MKADAVKISEGVYWVGTYDWDIRSYHGYTLKGTTYNAYLVFGDEKVAVIDNVYPGTSAQM
WGRIKDAFEKEGREFKIDVIVQNHVEKDHSGALVEITKKFPDAPIYCTEVAVEGLKKHYA
GLKNAPFKVIKSLESVDLGGKTLTFLEAPLLHWPDSMFTLYGEAGILFSNDAFGQHLCLT
KRFDNEIPENILMDANQKFYANLITPLSKLVLKKFNEVISLGLLEKITMIAPSHGQIWTD
PMKVISAYQNFATGQCKDKATIVYDTMHYSTQKMAHAFAEGLLSEGIEVVIYNLHSDERS
EIVKDILDSKAVLFGIPTINDQPFPSIGDLMYYLRGLRFDRTGFKKLALTFGSMGGRGGA
IEKIANELGSSGFDVVNEYELYYIPNEDELEKCYSLGNELGKNIKSI