Protein Info for MMP_RS05785 in Methanococcus maripaludis S2

Annotation: ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 614 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 296 to 314 (19 residues), see Phobius details PF14827: dCache_3" amino acids 43 to 279 (237 residues), 57.8 bits, see alignment E=4.6e-19 PF17201: Cache_3-Cache_2" amino acids 174 to 296 (123 residues), 50.3 bits, see alignment E=7.7e-17 PF17202: sCache_3_3" amino acids 190 to 291 (102 residues), 89.7 bits, see alignment E=5.4e-29 PF00672: HAMP" amino acids 314 to 363 (50 residues), 43.7 bits, see alignment 9.7e-15 PF00512: HisKA" amino acids 391 to 456 (66 residues), 68.9 bits, see alignment E=1.1e-22 PF02518: HATPase_c" amino acids 502 to 612 (111 residues), 116.4 bits, see alignment E=3.1e-37

Best Hits

KEGG orthology group: K02484, two-component system, OmpR family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to mmp:MMP1120)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 4.6.1.1

Use Curated BLAST to search for 2.7.13.3 or 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY71 at UniProt or InterPro

Protein Sequence (614 amino acids)

>MMP_RS05785 ATP-binding protein (Methanococcus maripaludis S2)
MRRSRIGMIGTKLLIFSIIIVLIPIVMMSYVSTDTISDLMTSNQESELDINLGILNERMD
SVLVEFDTMTAYTADLPVVVNAVKNNDKDTLQDFANGLEDQSWIDLAVFTDADGNVICAS
YGDDNAEISSYVKKLLEKNTIYAYDILPNEEASKYSEYELDGNDALTIFTVAPIYDGNSL
IGTVTYVDIMNKDDYWVDRVKEVTGDEASIYLNNVRISTTCIKDGVDFVGELADEDIYET
VSKKQDVRSTVTINGVPYLAKYSPIYNIDGEVIGMTCVGTPKSPFTALLNSVIQKIFFIA
FSSLIIAVFVAVILNKKIVDSIKKLKNSAESFGRGNYDERASIDTGDELEELAESFNKMA
DEIGKSDKKLKSDAHTLKTSFDELKEVDNLKSEILSIVSHELRTPLTAILGYVELLKDET
AGKLSEKQKEFISVISENSDRLKRITDNMSDLVTVDNKILDIKRDRINLKKEVNDILRSF
DYFAESKNIVLLEDVDNLDIKGDKSKIHQVLSNLIENAIKFSKKQTKVTVMGFEDKGNIH
LEITDQGPGIPKEHLGKIFDKFYQIDSSSKREVGGSGLGLAVCKKIVESHGGSIWVESKI
GKGTTVHVMFPLIK