Protein Info for MMP_RS05690 in Methanococcus maripaludis S2

Annotation: acetylornithine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00707: transaminase, acetylornithine/succinylornithine family
  • amino acids 16 to 392 (377 residues), 558.8 bits, E=2.6e-172
• PF00202: Aminotran_3
  • amino acids 23 to 391 (369 residues), 435.4 bits, E=2.7e-134
• PF01212: Beta_elim_lyase
  • amino acids 88 to 270 (183 residues), 28.9 bits, E=1.1e-10
• PF00155: Aminotran_1_2
  • amino acids 154 to 321 (168 residues), 23.6 bits, E=4.3e-09

Best Hits

Swiss-Prot: 74% identical to ARGD_METJA: Acetylornithine aminotransferase (argD) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 100% identity to mmp:MMP1101)

MetaCyc: 50% identical to succinylornithine transaminase subunit (Pseudomonas aeruginosa)
Succinylornithine transaminase. [EC: 2.6.1.81]; Ornithine aminotransferase. [EC: 2.6.1.81, 2.6.1.13]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.13, 2.6.1.11]

Predicted SEED Role

"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)

MetaCyc Pathways

• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-lysine biosynthesis I (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
• superpathway of arginine and polyamine biosynthesis (13/17 steps found)
• aspartate superpathway (18/25 steps found)
• L-proline biosynthesis III (from L-ornithine) (2/3 steps found)
• L-arginine degradation XIII (reductive Stickland reaction) (3/5 steps found)
• L-arginine degradation VI (arginase 2 pathway) (2/4 steps found)
• L-arginine degradation I (arginase pathway) (1/3 steps found)
• L-ornithine biosynthesis II (1/3 steps found)
• L-citrulline biosynthesis (4/8 steps found)
• L-arginine degradation II (AST pathway) (1/5 steps found)
• superpathway of L-citrulline metabolism (6/12 steps found)
• L-N^δ-acetylornithine biosynthesis (2/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.13 or 2.6.1.17 or 2.6.1.81

Sequence Analysis Tools

See Q6LY90 at UniProt or InterPro

Protein Sequence (395 amino acids)

>MMP_RS05690 acetylornithine transaminase (Methanococcus maripaludis S2)
MSTLEKEQIISDEKKYVIGTYGRVPVVLVKGNGMSVFDTDGKEYLDFLAGIGVNNVGHCH
PKVVEAIKNQAETLIHVSNIYYNVPQIELAKKLVNLSGLDKAFFCNSGAEANEAAIKLAR
KYAKANGKEGEIITMEHAFHGRTLTTITATPKAKYQEGFEPLPTGFKYIPFNDIDALKAG
ISEKTSAIMIEPVQGEGGIHPADNEYLKAVRKLCDENNIVLIFDEVQCGMGRTGTLFAYE
QYGVVPDIVTLAKGLGGGFPIGAMVAKSEIASAFTPGSHGTTFGGNPLACASSAAALDVI
SELLDNAVEMGEYFKNSLKTLEEKYEFVKEVRSLGLMVGIELTFNGSDIVSKMFEKGFLI
NCTSDTVLRFLPPLIVEKEHIDAMISALDEVFSEI