Protein Info for MMP_RS05630 in Methanococcus maripaludis S2

Annotation: flippase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 44 to 69 (26 residues), see Phobius details amino acids 84 to 107 (24 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 191 to 210 (20 residues), see Phobius details amino acids 232 to 252 (21 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 314 to 332 (19 residues), see Phobius details amino acids 352 to 372 (21 residues), see Phobius details amino acids 384 to 400 (17 residues), see Phobius details amino acids 406 to 428 (23 residues), see Phobius details amino acids 440 to 460 (21 residues), see Phobius details amino acids 466 to 486 (21 residues), see Phobius details PF01943: Polysacc_synt" amino acids 8 to 299 (292 residues), 112.1 bits, see alignment E=6.9e-36 PF13440: Polysacc_synt_3" amino acids 36 to 349 (314 residues), 41 bits, see alignment E=2.9e-14 PF03023: MurJ" amino acids 83 to 466 (384 residues), 39.6 bits, see alignment E=5.3e-14 PF01554: MatE" amino acids 238 to 397 (160 residues), 33.5 bits, see alignment E=6.7e-12

Best Hits

Swiss-Prot: 50% identical to Y1068_METJA: Uncharacterized membrane protein MJ1068 (MJ1068) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1089)

Predicted SEED Role

"Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYA2 at UniProt or InterPro

Protein Sequence (500 amino acids)

>MMP_RS05630 flippase (Methanococcus maripaludis S2)
LSYKERMIKGASWNFLFLVLAAPIGYFVRILYANSLSKVEVGLFYAILDLISMVSIFRGL
GLNNTVIYFIPKFLVQNRKDLIKSTLISVLLIQTIMAVLMAVLMYLISPTLINKYINNQG
QFGDISLIFVVFTIMIFGYYIFDGTKALLFNSFQGFQSQKIYGTCNFLNILSILILSIIF
IYFGAGLYSPALAYTITPLIMILIYGKIFLKEVFPEFFTEKITFSKELLNDIFSYGMPIM
FGSAGFIIMGYLDSICLTYFTGLNAVADYRNVAMPTVLVLSYFASAICKVILPMSTEMWE
KGEKKNLSDGLKKILSYSFIISVPFAVILAYFPTELVNIFFNENYLTAAPTMSILSFGVI
FLSMNTIVFDIFNGIGKPHLSAKILYIGALFNLIFNLLLIPKFGTIGAAFATTLCYILIQ
ILQTRYLGKFLDYKFPLKNFFLCLFSSSISIVPLLIIKSMILNEYVLILFSGVLYFLTYF
LSIYVLKVDDLKEIKSLIFK