Protein Info for MMP_RS05590 in Methanococcus maripaludis S2

Annotation: N-acetyl sugar amidotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 370 TIGR03573: N-acetyl sugar amidotransferase" amino acids 4 to 339 (336 residues), 376.1 bits, see alignment E=1e-116 PF02540: NAD_synthase" amino acids 52 to 120 (69 residues), 21.3 bits, see alignment E=6.6e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1081)

MetaCyc: 45% identical to UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate amidotranferase (Pseudomonas aeruginosa PAO1)
3.5.3.-

Predicted SEED Role

"putitive LPS biosynthesis protein"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYB0 at UniProt or InterPro

Protein Sequence (370 amino acids)

>MMP_RS05590 N-acetyl sugar amidotransferase (Methanococcus maripaludis S2)
MVQKICKRCIMDMTDPNIVFDENGYCNHCYNALEQNSKIKVNMAEKNKELKKIVNLIKKN
GKNKRYDCIIGVSGGVDSTYVAYLVKKLGLKPLAVHLDNGWNSELAIMNIENTLKKLDID
LYTRVLNWEEFKDLQLSFLKASVPDLEIPTDHAIIATLYEVAHKFGIKYIISGHNIITES
IGVPMWSNGHYDWKYISGLQKKFGNIKLLDYPKMTPLNIFYYQFIKDIKMIRILNYADYD
KKRVVELIEKEFSWKDYPTKHGESIYTHFIQSYILPEKFGYDKRKCHLSNLICSEQITRA
EALGQFKKPLFTPQELEELINYSCDKLEISRKEFESLMKLPNKSYYDYPSYENSKFYKFL
RETYKKIRVY