Protein Info for MMP_RS05195 in Methanococcus maripaludis S2

Annotation: phosphoribosylanthranilate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00697: PRAI
  • amino acids 4 to 201 (198 residues), 93.9 bits, E=5.5e-31

Best Hits

Swiss-Prot: 100% identical to TRPF_METMP: N-(5'-phosphoribosyl)anthranilate isomerase (trpF) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01817, phosphoribosylanthranilate isomerase [EC: 5.3.1.24] (inferred from 100% identity to mmp:MMP1004)

Predicted SEED Role

"Phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 5.3.1.24)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• superpathway of L-tryptophan biosynthesis (12/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of chorismate metabolism (25/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.24

Sequence Analysis Tools

See Q6LYI7 at UniProt or InterPro

Protein Sequence (211 amino acids)

>MMP_RS05195 phosphoribosylanthranilate isomerase (Methanococcus maripaludis S2)
MFIKICGIKTPEELRIVENYGNATGVILECASKRRIGFETAKNLVNLANIPVFAVSTASD
VSVWENIIEFTGTNYLQMHSDIDQKAIDFIKNEYGCFIMKSFKIPETSTSPEIDAEKIIS
EIESYEVDRILLDTGKGCGQTHDHRVSQIIAKKFDIVLAGGLDPDNVLNIVKYVKPFGID
VSSGVENNNSKDEELIKRFCENVKLGENYEM