Protein Info for MMP_RS04680 in Methanococcus maripaludis S2

Annotation: NOG1 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 345 PF17835: NOG1_N" amino acids 10 to 170 (161 residues), 123.3 bits, see alignment E=3.2e-39 TIGR00231: small GTP-binding protein domain" amino acids 174 to 304 (131 residues), 50.9 bits, see alignment E=7.6e-18 PF10662: PduV-EutP" amino acids 176 to 330 (155 residues), 21.7 bits, see alignment E=4.6e-08 PF01926: MMR_HSR1" amino acids 176 to 291 (116 residues), 73 bits, see alignment E=6.6e-24 PF02421: FeoB_N" amino acids 176 to 328 (153 residues), 54.4 bits, see alignment E=3.1e-18 PF06858: NOG1" amino acids 237 to 293 (57 residues), 72.3 bits, see alignment E=6.7e-24

Best Hits

Swiss-Prot: 57% identical to Y1408_METJA: Uncharacterized protein MJ1408 (MJ1408) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06943, nucleolar GTP-binding protein (inferred from 100% identity to mmp:MMP0901)

Predicted SEED Role

"GTP-binding protein, gtp1/obg family" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYT6 at UniProt or InterPro

Protein Sequence (345 amino acids)

>MMP_RS04680 NOG1 family protein (Methanococcus maripaludis S2)
MRKSRDANPFKAMPNILYPDELMDKAYNRSEKIAGELRTTTRGLSTPKSKIIEDNKIRTT
ASVISDNLLKIVEKTPSIDNLDPFYREILEIMVGSDEFKKSLAAVQWASEIVKKLGTQYS
RKVKKAPSPQATSIVRKEFIGRVSSVLKQIYPNMAFLGVARNKLKNIPTVKNLPSVVIAG
YPNVGKSTLLRTLTDAEPEVNSYPFTTKGLNIGYTEEGIQIIDTPGVLDRPIYERNDIEL
HAVVAINYLSDMILFVIDPTEFCGFTMEEQFNLLQEIRKTFNVPILVALTKMDVDEIEGL
DKLEEDLGEYEVLKVSSFKKEGIADLRERLLDILDEQGLMGLLEE