Protein Info for MMP_RS04600 in Methanococcus maripaludis S2

Annotation: tetratricopeptide repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 388 PF13432: TPR_16" amino acids 17 to 79 (63 residues), 31.2 bits, see alignment E=3.1e-10 amino acids 117 to 178 (62 residues), 31.5 bits, see alignment E=2.5e-10 amino acids 218 to 281 (64 residues), 20.7 bits, see alignment E=5.9e-07 amino acids 286 to 344 (59 residues), 22.1 bits, see alignment E=2.2e-07 PF13181: TPR_8" amino acids 19 to 45 (27 residues), 12.1 bits, see alignment (E = 0.00026) amino acids 47 to 79 (33 residues), 27.4 bits, see alignment 3.2e-09 amino acids 117 to 143 (27 residues), 14.1 bits, see alignment (E = 5.8e-05) amino acids 147 to 176 (30 residues), 19.8 bits, see alignment (E = 8.8e-07) amino acids 248 to 278 (31 residues), 15.2 bits, see alignment (E = 2.5e-05) amino acids 283 to 309 (27 residues), 16.5 bits, see alignment (E = 9.7e-06) amino acids 315 to 348 (34 residues), 21.8 bits, see alignment 2e-07 amino acids 350 to 380 (31 residues), 13.9 bits, see alignment (E = 6.9e-05) PF13414: TPR_11" amino acids 19 to 60 (42 residues), 28.9 bits, see alignment 9.8e-10 PF00515: TPR_1" amino acids 46 to 79 (34 residues), 33.6 bits, see alignment 3e-11 amino acids 315 to 348 (34 residues), 33.8 bits, see alignment 2.6e-11 PF07719: TPR_2" amino acids 46 to 79 (34 residues), 26.4 bits, see alignment 6.5e-09 PF13429: TPR_15" amino acids 109 to 241 (133 residues), 30.4 bits, see alignment E=3.5e-10 PF14559: TPR_19" amino acids 157 to 211 (55 residues), 29.3 bits, see alignment 1.1e-09 PF13174: TPR_6" amino acids 220 to 243 (24 residues), 12.4 bits, see alignment (E = 0.0003)

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0885)

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYV2 at UniProt or InterPro

Protein Sequence (388 amino acids)

>MMP_RS04600 tetratricopeptide repeat protein (Methanococcus maripaludis S2)
MGLLSIFKSKDPKKLLETGTEYYNSGKYQKSIEYFNKTLNSEPKNPDAWYFKGNAYHMLG
KSKLAQDSYEKALSIRPNDLEIIKSYTMLLNSLELFKESVEILKNVSESDDKIIEILGDA
YLKTGKFNEAILQYNNILERKPRYKEILAKKGTALVGLKKFDEALEIYEKVLKISPYDTE
VWKNIGNAFYTVKKYEKAIQFYDMYLNEHKGDFGVTLSKGDALRKLGKTNEALDLYTKVL
EKHIQNYEPWCRVGLLYYDTEDYETAIYYLELANERNPLNPSILVKLGRTYVKLRNYNKG
LEFMEKALDKDSEYAKAWCYKGYILNLLERHYEAIDCYKKAISINKNDSKFWMHLSNVYK
TIGKEDYSKEAYENAVNLENHNMLPKSA