Protein Info for MMP_RS04515 in Methanococcus maripaludis S2

Annotation: betaine/proline/choline family ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 TIGR01186: glycine betaine/L-proline transport ATP binding subunit" amino acids 38 to 387 (350 residues), 352.5 bits, see alignment E=1.3e-109 PF00005: ABC_tran" amino acids 45 to 194 (150 residues), 122 bits, see alignment E=4.4e-39

Best Hits

KEGG orthology group: K05847, osmoprotectant transport system ATP-binding protein (inferred from 100% identity to mmp:MMP0868)

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYW7 at UniProt or InterPro

Protein Sequence (389 amino acids)

>MMP_RS04515 betaine/proline/choline family ABC transporter ATP-binding protein (Methanococcus maripaludis S2)
MDEPIIQVTELYKIFGKKPEKAYPLIKEGFSRQEIKEKTKQVVGLRNINFDVKRGEIFVI
MGLSGSGKSTLIRCINRLIKPTFGKIVLETGADISQMSEKELLEIRRKYFGMVFQKFGLL
PNRSVLENVALGLEIQGMGLEERIEKSEKALSLVGLKGWEKSKISELSGGMQQRVGLARG
LAVNPEILLMDEPFSALDPLIRLEMQELLLKIQKKMKKTIIFITHDLNEAIKLGDRIMIL
NEEGSLVQLSHPEEILLNPQNDFVESFVKDVDKTTVIRAESLVKKPEFTLNNTIEKENAV
KILGELNLDFAYVLDDSGKYIGVVNNEELQNSEKIMDCIHKIKPLEDVKTINQGLPQFIS
SDYPVPIVDDENNFLGYVEFEEVIKLIKE