Protein Info for MMP_RS04355 in Methanococcus maripaludis S2

Annotation: ribonuclease H family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 201 PF01693: Cauli_VI" amino acids 3 to 46 (44 residues), 68.3 bits, see alignment 8.1e-23 PF00075: RNase_H" amino acids 68 to 199 (132 residues), 48.3 bits, see alignment E=1.8e-16 PF13456: RVT_3" amino acids 72 to 198 (127 residues), 28.2 bits, see alignment E=2.4e-10

Best Hits

KEGG orthology group: K03469, ribonuclease HI [EC: 3.1.26.4] (inferred from 100% identity to mmp:MMP0837)

Predicted SEED Role

"Ribonuclease HI-related protein" in subsystem Ribonuclease H

Isozymes

Compare fitness of predicted isozymes for: 3.1.26.4

Use Curated BLAST to search for 3.1.26.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYZ2 at UniProt or InterPro

Protein Sequence (201 amino acids)

>MMP_RS04355 ribonuclease H family protein (Methanococcus maripaludis S2)
MSKIYAVRKGRKMGLFNTWAECENQVKGFSGAEFKSFKSKIDAEDYLNLKSGQNQNNIKS
DEFKKDVMHAWVDGSFNLKNKEYGAGALILFNGIEKEIKAKGNDTELSKMRNVAGEILAS
ELAMEYAVSKNVKNLVIYHDYIGIEKWCTGEWKTNKSGTIEYIEKCINYLKKLNIEFVKV
KAHSGDKNNEIADKLAKESLL