Protein Info for MMP_RS04115 in Methanococcus maripaludis S2

Annotation: cytosine permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 transmembrane" amino acids 24 to 44 (21 residues), see Phobius details amino acids 56 to 78 (23 residues), see Phobius details amino acids 98 to 121 (24 residues), see Phobius details amino acids 132 to 151 (20 residues), see Phobius details amino acids 157 to 181 (25 residues), see Phobius details amino acids 195 to 215 (21 residues), see Phobius details amino acids 227 to 250 (24 residues), see Phobius details amino acids 263 to 284 (22 residues), see Phobius details amino acids 305 to 322 (18 residues), see Phobius details amino acids 328 to 349 (22 residues), see Phobius details amino acids 368 to 403 (36 residues), see Phobius details PF02133: Transp_cyt_pur" amino acids 16 to 388 (373 residues), 164.6 bits, see alignment E=1.8e-52

Best Hits

Swiss-Prot: 57% identical to CODB_ECO57: Cytosine permease (codB) from Escherichia coli O157:H7

KEGG orthology group: K10974, cytosine permease (inferred from 100% identity to mmp:MMP0789)

MetaCyc: 57% identical to cytosine transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-116

Predicted SEED Role

"Cytosine permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZ40 at UniProt or InterPro

Protein Sequence (411 amino acids)

>MMP_RS04115 cytosine permease (Methanococcus maripaludis S2)
MSQQKHADQDYALETVPSESKKGFLPMFAIMLGFTFFSASMWAGGTIGTGLKFQTFLLAV
LMGNLLLGLYTGALAYIGSSTGLSTHLLARYSFGEKGSYLASFILAITQVGWFGVGVAMF
SLPVHYATGIDLNILLLLSGILMTTTAYFGIKSLTVLSMISVPAITLLGIYSVTGAVNSI
GGISELFAIEPANNLGLAVGLSLCIGSFISGGTLTPDFSRFSKSKSIGVISTFIAFFIGN
SLMFIFGAVGASTLGQSDISEVMLKQGLIIPAIIILGLNIWTTNDNALYASGLGFSNITK
IPKKHVVIFNGLIGTLGALVLYNNFVGWLTLLSSIIPSIGGIIISDYFINKRQKYASLEN
IKVKKVHWNAVIAWVLGVFASQFLPGISPINAVFGSAIIYIVLETLKKNNI