Protein Info for MMP_RS03900 in Methanococcus maripaludis S2

Annotation: minichromosome maintenance protein MCM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 668 PF17207: MCM_OB" amino acids 102 to 208 (107 residues), 47.7 bits, see alignment E=3.3e-16 PF00493: MCM" amino acids 260 to 478 (219 residues), 234.7 bits, see alignment E=1.9e-73 PF07728: AAA_5" amino acids 312 to 429 (118 residues), 26.5 bits, see alignment E=1.4e-09 PF01078: Mg_chelatase" amino acids 360 to 430 (71 residues), 21.3 bits, see alignment E=4e-08 PF17855: MCM_lid" amino acids 507 to 583 (77 residues), 82.6 bits, see alignment E=5.9e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0748)

Predicted SEED Role

"DNA replication helicase protein MCM" in subsystem DNA replication, archaeal

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZ81 at UniProt or InterPro

Protein Sequence (668 amino acids)

>MMP_RS03900 minichromosome maintenance protein MCM (Methanococcus maripaludis S2)
MDDKKIHELRLYLVDYLKAYHLDDFRLEKYRVKVDIKNIYENYGFEFVNYLEEEPKEAVN
LLEEAYTEAYYSVKGDKPHFVLSIYNLPDTINKKSGKVVTIEDINVETHGRLLEVEGIIV
LATKIKMALKRGVHLCTSCGEKKIEYIEKPFEAQFEPVCPKCAQNMMLLEDDSKTKYVNF
QELKLQQPLDLMSDPEEPPKFITVLLENSPGFYTGRVKVTGIPIKIQRNKKVPMYDLVFS
GIHCEPVSEKLESDFTENEIESFEKIAKNENVIEILADRLIPDLKGYMTVKKAVFLQQVK
GVKKGNKRNDSHILLITDPGTGKSLSLRKIAKIPGNVYGSVNMASGVGLTASVVQEKTEI
GDNTYVIKPGLLVKANGGTACIDEFATNKKLHENLLEAMESQTIHISKGGLNTKLPSECA
VLAAGNPRWGRFDPNVSIMEQINISPPILSRFDLIFPLIDEPDRTKDRGIAHHIISIHRA
HLDKGKDKEIDLTSKVIDDIEIDFGFICKYITYARQLEPKITDEAENILTDYYLKMRKGV
VQITARQLEAAIRLSEAIAKARLKTEVTCEDALEAVELINESLKETAFDPETGQYDVDKI
MGVSKKERSRLTEVYDAIKDLGSIKDLVLYDDLLEALKMKETILKEAIKKLITNGDIDEP
KTGMYRII