Protein Info for MMP_RS03815 in Methanococcus maripaludis S2

Annotation: excinuclease ABC subunit UvrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 TIGR00630: excinuclease ABC subunit A" amino acids 4 to 933 (930 residues), 1410.4 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 233 (104 residues), 109.3 bits, see alignment E=3.3e-35 PF17755: UvrA_DNA-bind" amino acids 288 to 398 (111 residues), 99.7 bits, see alignment E=4.2e-32

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 100% identity to mmp:MMP0729)

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZA0 at UniProt or InterPro

Protein Sequence (951 amino acids)

>MMP_RS03815 excinuclease ABC subunit UvrA (Methanococcus maripaludis S2)
MKDIIIKGAREHNLKNISLTLPRNNLIVVTGVSGSGKSTIAFDTIYAEGQRRYVESLSAY
ARQFLGLMNKPDVDSIEGLSPAIAIQQKTTSKNPRSTVGTVTEIYDYLRLLYARIGIPYC
PEHNIRIESQSPEKIAEKIEEEFSETVTILSPIVRQKKGTYQKLFKDLNSEGFARIRVNG
EIYRTDDEITLERYKKHDIEIVIDRLTPKDDHSRLVEACERALERSGGLLIVTGTKNNEE
IEKIYSSNLACPICGISFEELQPRMFSFNSPFGACEYCSGLGIKMEFDADLIIPDKNKCI
ADGAVALYRNFLDGYRSQHLAAVANHFGFTVLTPIKDLSKEQLDILMYGSPEKIHFKVSN
GSGDTEWSQNKPWEGLIPQSIRLYNETKSEYRRKELEKFMKVSLCPKCGGKRLKDKALAV
KIEDKSIIDLTDLSISKAEEFFNNLKLTDKEYEIAKQVIKEIKSRLKFLNDVGLGYLTLS
RRSGTLSGGEAQRIRLATQIGSNLTGVLYVLDEPSIGLHQRDNQKLIETLHKLRNLDNTL
VVVEHDEDTILNADYVVDMGPGAGVHGGDVVAVGTPMEISKNKDSLTGKYLSGELKIEIP
KNRRKSDKFLKLSNCRQNNLKDVSVEIPTGVFNVITGVSGSGKSTLIYENLYPALKEKIK
SDESVGELDFEDQLYENTKEKCNLEINSEIDKVVVIDQSPIGRTPRSNPATYTKVFDKIR
QVFAETKEAKIKGYGPGRFSFNVKGGRCENCQGDGVIKIEMNFLPDVFVECEECKGARYN
HETLEVKYKGKSISDVLNMSVEEAREHFKNIPQISNKLKTLCDVGLGYIKLGQSSTTLSG
GEAQRIKLTRELSKRATGNTIYLLDEPTTGLHFHDVKKLIDVLNSLVEKGNTVVVIEHNL
DVIKCADHIIDLGPEGGEFGGEIIATGTPEEIAKCKLSHTGKFLKNILSKN