Protein Info for MMP_RS03810 in Methanococcus maripaludis S2

Annotation: excinuclease ABC subunit UvrC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 TIGR00194: excinuclease ABC subunit C" amino acids 4 to 524 (521 residues), 513.8 bits, see alignment E=3.3e-158 PF01541: GIY-YIG" amino acids 11 to 86 (76 residues), 43.4 bits, see alignment E=6.9e-15 PF02151: UVR" amino acids 192 to 225 (34 residues), 27.7 bits, see alignment (E = 3.4e-10) PF22920: UvrC_RNaseH" amino acids 239 to 353 (115 residues), 73.3 bits, see alignment E=3.2e-24 PF08459: UvrC_RNaseH_dom" amino acids 366 to 514 (149 residues), 186.4 bits, see alignment E=6.6e-59

Best Hits

Swiss-Prot: 100% identical to UVRC_METMP: UvrABC system protein C (uvrC) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K03703, excinuclease ABC subunit C (inferred from 100% identity to mmp:MMP0728)

Predicted SEED Role

"Excinuclease ABC subunit C" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZA1 at UniProt or InterPro

Protein Sequence (527 amino acids)

>MMP_RS03810 excinuclease ABC subunit UvrC (Methanococcus maripaludis S2)
MINISDIPKNPGCYIYKNESGTVIYVGKAKNLKKRVSSYFNKKNHDPKTEKLVKSIYEME
FIVTDNEVEALILENTLIKKYSPKYNIDLKDSKNYAYIYISEENFPRIGISRNKSKKGKF
YGPFTSAKERDYVLDVLKKTFKIRSCKNMHKRPCLRHHIKNCTAPCSGDITSKDYLNQIK
KAEHILKGNIDSLIHELKNEMNEKSKNLQFEEALLIREEINAIERLKTRQNVKRDVKYNE
DVISILEKSGKLHIMVFNVLKGTLFDRKYFEFDYTENFFEEFLIQYYSENDVPSEIIISE
LPKNLEEDNNEYSSDALLEYLSKKKGSKVAFKIPKQGEKKQLLDLAIKNLEIYVNGNEIK
VQSLKNKLMLDKSPNIIECFDISHLSGTSTVGSVVQFRNGKPDKKNYRRFKIKTVSGIDD
FKSISEVVFRRYSKLLEENLELPDLIIIDGGKGQLSSAFSELRKLKLKIPLISIAKREEE
IYTPGIENPLPIKKNEKASLFIQEIRDEAHRFAINYNRLLRKKELIK