Protein Info for MMP_RS03770 in Methanococcus maripaludis S2

Annotation: hydroxylamine reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 546 TIGR01703: hydroxylamine reductase" amino acids 7 to 544 (538 residues), 760.2 bits, see alignment E=5e-233 PF03063: Prismane" amino acids 7 to 541 (535 residues), 583.5 bits, see alignment E=2e-179

Best Hits

Swiss-Prot: 77% identical to HCP_METVS: Hydroxylamine reductase (hcp) from Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)

KEGG orthology group: K00378, hydroxylamine reductase [EC: 1.7.-.-] (inferred from 100% identity to mmp:MMP0720)

Predicted SEED Role

"Hydroxylamine reductase (EC 1.7.-.-)" in subsystem Nitrosative stress (EC 1.7.-.-)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZA9 at UniProt or InterPro

Protein Sequence (546 amino acids)

>MMP_RS03770 hydroxylamine reductase (Methanococcus maripaludis S2)
MERPTKMYCNQCQETVKGTGCVKVGVCGKKDNVANLQDLLIYTLKGISYVSEKTGENNGA
IDRYIVDSLFASVTNTNFDDKYLIENVKEGLKLRDSLKSKCGGNCGQLPDFATWNAKTDL
EILEKSNSKEVSLQATENEDIRALRVTTLYGLKGIAAYLHHAMVLGENSGEIHKFIKKAL
IDISDDSKSADELTALVLETGKYAVDTMALLDKANTTKYGNPEITEVDIGVRENPGILIS
GHDLKDMEDLLEQTKGTGIDVYTHSEMLPAHYYPEFKKYEHFAGNYGGSWYKQKTEFESF
NGPILMTTNCIVPPADSYVDRIYTTGVVGYPGLKYIPTVNGKKDFSEVIEQAKKCPSPVE
LETGKIVGGFAHNQVLALADKVVDAVKSGAIKKFFVMAGCDGRNSDREYYTEFAKNLPKD
TVILTAGCAKYRYNKLNLGDIGGIPRVLDAGQCNDCYSLAVIALKLKEVFELDDINKLPI
AFNIAWYEQKAVAVLLALLYLGIKNIHVGPTLPEFLSPNVAKVLIDKFELGGISSVEEDM
KMFLGE