Protein Info for MMP_RS03610 in Methanococcus maripaludis S2

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 50 to 71 (22 residues), see Phobius details amino acids 77 to 97 (21 residues), see Phobius details amino acids 103 to 122 (20 residues), see Phobius details amino acids 136 to 158 (23 residues), see Phobius details amino acids 169 to 189 (21 residues), see Phobius details amino acids 196 to 220 (25 residues), see Phobius details amino acids 238 to 263 (26 residues), see Phobius details amino acids 286 to 307 (22 residues), see Phobius details amino acids 318 to 337 (20 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 375 to 403 (29 residues), see Phobius details amino acids 414 to 432 (19 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 22 to 394 (373 residues), 163.9 bits, see alignment E=2.5e-52

Best Hits

Swiss-Prot: 71% identical to Y326_METJA: Putative permease MJ0326 (MJ0326) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 100% identity to mmp:MMP0689)

MetaCyc: 37% identical to guanine/hypoxanthine transporter GhxQ (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-562; TRANS-RXN0-578

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZE0 at UniProt or InterPro

Protein Sequence (433 amino acids)

>MMP_RS03610 NCS2 family permease (Methanococcus maripaludis S2)
MANFLARYFGFEEHKTNFKVETMAGVTTFMTMAYIIFVNPSILSLAGMDFGAVMVATCIS
AALGTFIMGVYAKYPFALAPGMGLNAFFTFGVVMGMGLSWQTALGAVFISGILFILLTLT
KIRTWIFDAIPDALKYGTAVGIGLFIAFIGLKSAGVIVANEATLVGLGNVLSPATFLALF
GLFATAAMMARKVTGAILWGIILTAVIGMGLGVSALPAGLVAMPPSLAPTLMQMDVMGAL
SFGLINIILAFFFVDLFDTLGTLSALSSQAGYMKDGKLPKAEKALMSDSVATAVGAALGT
STVTSYVESASGIGLGGRTGFVSVVVAALFLLSIFFSPFVAAIPAYATAPALIIVGALMI
SAIKRIDLDDITESVPAFIALITIPLTYSIATGLQLGFIFYPLIKIIAGRSKEVHPIVYL
LAIIFAARFVYIG