Protein Info for MMP_RS03495 in Methanococcus maripaludis S2

Annotation: Na/Pi cotransporter family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 47 to 74 (28 residues), see Phobius details amino acids 87 to 89 (3 residues), see Phobius details amino acids 99 to 123 (25 residues), see Phobius details amino acids 135 to 153 (19 residues), see Phobius details amino acids 173 to 200 (28 residues), see Phobius details amino acids 204 to 228 (25 residues), see Phobius details amino acids 240 to 265 (26 residues), see Phobius details amino acids 284 to 305 (22 residues), see Phobius details TIGR00704: Na/Pi-cotransporter II-related protein" amino acids 9 to 310 (302 residues), 235.7 bits, see alignment E=4.7e-74 PF02690: Na_Pi_cotrans" amino acids 15 to 150 (136 residues), 179.9 bits, see alignment E=2.5e-57 amino acids 144 to 255 (112 residues), 62 bits, see alignment E=6.6e-21 PF01895: PhoU" amino acids 345 to 429 (85 residues), 58.6 bits, see alignment E=6.4e-20 amino acids 452 to 531 (80 residues), 61.9 bits, see alignment E=6.2e-21

Best Hits

KEGG orthology group: K03324, phosphate:Na+ symporter (inferred from 100% identity to mmp:MMP0666)

Predicted SEED Role

"Sodium-dependent phosphate transporter" in subsystem Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZG3 at UniProt or InterPro

Protein Sequence (541 amino acids)

>MMP_RS03495 Na/Pi cotransporter family protein (Methanococcus maripaludis S2)
MEFALIAGVLGGLALFIYGMNLMGNGLQKVAGDGLKRLIEVLTKNKYLGVLVGTVVTMLI
QSSSATTVMVVGFVNASLMNLTQAIGVIMGANIGTTVTAQLVAFKLTDIAPLIVAVGVIM
QLVSKKRKHSDIAEVLIGFGILFIGMHTMSSVLKPLAGEPFFTDLLMNLENPVLGLFVGL
GMTLMIQSSSATIGLLIAVASTGALSLAVAFPILFGDNIGTCVTALLSSIGANRTAKRAA
LMHLIFNITGALIFMVLIYTTPLISWIQSLSAGSVERQIANAHTIFNVTNTLIMLPFAGF
FVYAVEKLIPIKDYEKEFMPIKHLDSRIIMETPSIAVGLGVKEVVEMGKFVRENLRLSKE
ALVNKNVQSIKEVHEKEKIIDTMAHEITNHLIELSNQEISDSQKLKITSLISNVTSLERI
GDLAEDIVEHAENVIEDNIEFTNTAVDELNFMFDKVIVSIDIAIEAFETEDEVLVEKVTF
LEDEVDNLEKTFRKQHIKRLNAKECAPKASIVFLDIIGYLERISDHAVKIATGLEEEEFD
A