Protein Info for MMP_RS03470 in Methanococcus maripaludis S2

Annotation: phosphoadenosine phosphosulfate reductase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 PF02540: NAD_synthase" amino acids 53 to 172 (120 residues), 23.3 bits, see alignment E=3.3e-09 PF01507: PAPS_reduct" amino acids 69 to 171 (103 residues), 24.9 bits, see alignment E=1.9e-09

Best Hits

Swiss-Prot: 53% identical to Y1599_METJA: Uncharacterized protein MJ1599 (MJ1599) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0661)

Predicted SEED Role

"TilS-like type 2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZG7 at UniProt or InterPro

Protein Sequence (291 amino acids)

>MMP_RS03470 phosphoadenosine phosphosulfate reductase family protein (Methanococcus maripaludis S2)
MEKIKGKNTVNCEICLHNSKTRPMFKHEGKNICIECLNALKFPRNFEEMKNEVMDYLDEL
RIRNNKYNCILGFSGGKDSVVALYLLVKELRIRPLCVTVDNGYLAEEALTNCKNVAKYFG
VDWLVINKDFTKFFKETISKGESPCRVCSDMNMHELWQFARQTNIDTIVTGHELPFGTTA
IRGMKKGINMLRLLVAYKLTEEDRYNILKEIPWEKPDLGGYTTNCLVLAPALVEFKKKHG
FSFEYDRVSAMIRYGLMTREEAEEALKCPEVSDEIYEELKKRGLDFKNLKE