Protein Info for MMP_RS03405 in Methanococcus maripaludis S2

Annotation: RNA 3'-terminal phosphate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 339 TIGR03399: RNA 3'-phosphate cyclase" amino acids 4 to 319 (316 residues), 373.1 bits, see alignment E=5.9e-116 PF01137: RTC" amino acids 10 to 321 (312 residues), 269.3 bits, see alignment E=2e-84 PF05189: RTC_insert" amino acids 187 to 270 (84 residues), 36 bits, see alignment E=8e-13

Best Hits

Swiss-Prot: 55% identical to RTCA_METJA: RNA 3'-terminal phosphate cyclase (rtcA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01974, RNA 3'-terminal phosphate cyclase [EC: 6.5.1.4] (inferred from 100% identity to mmp:MMP0648)

Predicted SEED Role

"RNA 3'-terminal phosphate cyclase (EC 6.5.1.4)" in subsystem RNA 3'-terminal phosphate cyclase (EC 6.5.1.4)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.5.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZI0 at UniProt or InterPro

Protein Sequence (339 amino acids)

>MMP_RS03405 RNA 3'-terminal phosphate cyclase (Methanococcus maripaludis S2)
IFMITIDGSYLEGGGQIVRTAVSLSAITKKPVKIINIRKNRKNPGLSNQHIACVAAVSKI
CNAKVEGLIKGSETLVFYPGKIISKNFEIDIKTAGSISLVIQSILPISLAIDKNVEITII
GGTNVEFSPPIDYIKNITLKFLENIGINSEITILKRGFFPKGGGIVKITIKPSKINPYEL
IENENIEIKGIVFNQNLDENISKRIRKSASDELLNRGFCPEIKLEKINGESAGVGIFLYT
NYIGSDRLGKKGLLSEAVGTTASEKLLEELNTKMAIDSHLADQIIPFMPFSDITIGVSKI
TNHTLTNIYVVEKFFDVKFNIEKYEEKNANGYIISTKGV