Protein Info for MMP_RS03355 in Methanococcus maripaludis S2

Annotation: beta-propeller domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 745 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF09826: Beta_propel" amino acids 92 to 614 (523 residues), 404.1 bits, see alignment E=9.8e-125 PF09394: Inhibitor_I42" amino acids 654 to 741 (88 residues), 96.5 bits, see alignment E=9.3e-32

Best Hits

KEGG orthology group: K14475, inhibitor of cysteine peptidase (inferred from 100% identity to mmp:MMP0638)

Predicted SEED Role

"Uncharacterized protein MJ1554 precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZI9 at UniProt or InterPro

Protein Sequence (745 amino acids)

>MMP_RS03355 beta-propeller domain-containing protein (Methanococcus maripaludis S2)
MNRNIIIILGLILITSAVFLTYNPKDDFGISYTGDFNMVPADSEGNFNNFLELASDSGYY
YGSDNIAVKEDMVYATANEDSLMASGYSDARYSETNVQLAGVDEADIVKTNGKYIFYTTQ
SPAWVNYYGGQSTYVIDALPPETARVIGNITDGGNLYLDGDNLIVITYDGIKNYNISNPK
TPELIWAKDLNGSYVDSRLIDGELYLIVQEYGINGPIIWNNVKIGYDDIYLPVIPEIIRQ
NFETTYIISSINVESGEIENTAALVGSYSNTVYVSEENIYFAYELDYDEDKLMMKFVAEN
GDKYFPKEVTDKLDRVFSNTDFGDSAKYVQMTEILEDYINTLSSEEMNNLENEIENDYEI
YLKENWEELEGTGIAKISLDDFKVTSGKVPGTILNSFSMDEYDGNLRIATTIGNDWRYRD
IQTNNIYVFDENMDVIGKVTGLEEGERIYSARFIGDKAYVVTYKETDPLLVIDLQDPNNP
EVLGELKIPGYSTYLHPIGNNKLIGIGKDDSNMVKISLFDATDLENPKELSKYSLNEYWS
AALYEHHAFLWDSEKEILVLPAGSHAYAFEVKESGIKMVKDDVFKDYSVLRSLYIGDYLY
TFSNYEIHVIDENTWKTVKTIDLPKYEYPYLEPYIEPVEDFADVEIETIDEKVVIGENIT
IKLDENPTTGYTWNYSISDDGKIELLFDEYIQDEVEDGIVGAGGVHEWTFNATESGEVEI
TFDYYRSWEGVGGSINTIIYKITVE