Protein Info for MMP_RS03185 in Methanococcus maripaludis S2

Annotation: KH domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 184 PF00013: KH_1" amino acids 6 to 52 (47 residues), 23.6 bits, see alignment E=5.3e-09 amino acids 105 to 153 (49 residues), 21.6 bits, see alignment E=2.2e-08 TIGR03665: arCOG04150 universal archaeal KH domain protein" amino acids 8 to 179 (172 residues), 235.7 bits, see alignment E=1.3e-74 PF17903: KH_KRR1_1st" amino acids 11 to 84 (74 residues), 26.5 bits, see alignment E=8.9e-10 PF21800: KH_KRR1_2nd" amino acids 87 to 155 (69 residues), 35.9 bits, see alignment E=9.1e-13

Best Hits

Swiss-Prot: 65% identical to Y443_METJA: KH domain-containing protein MJ0443 (MJ0443) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06961, ribosomal RNA assembly protein (inferred from 100% identity to mmp:MMP0605)

Predicted SEED Role

"Putative RNA-binding protein COG1094"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZL9 at UniProt or InterPro

Protein Sequence (184 amino acids)

>MMP_RS03185 KH domain-containing protein (Methanococcus maripaludis S2)
MYENVEVVKIPKERTGILIGTHGEVRKKLESDLGVELEIDSEGEVNIYSTDEQKDPLALW
KARDIVKAIGRGFNPEKALKLVSDEYAFEVIDISEYGNSDKAIQRLKGRIIGSSGKSRRY
VEELTSTHISVYGKTVSIIGEIETAKIAKDAIEMLLRGTSHSKMYKFLERHRQDVKRSEL
RLWK