Protein Info for MMP_RS03075 in Methanococcus maripaludis S2

Annotation: valine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 886 TIGR00422: valine--tRNA ligase" amino acids 5 to 861 (857 residues), 1009 bits, see alignment E=8.6e-308 PF00133: tRNA-synt_1" amino acids 15 to 565 (551 residues), 367.8 bits, see alignment E=1e-113 PF09334: tRNA-synt_1g" amino acids 37 to 186 (150 residues), 56.3 bits, see alignment E=3.6e-19 amino acids 451 to 571 (121 residues), 26.7 bits, see alignment E=3.6e-10 PF08264: Anticodon_1" amino acids 613 to 760 (148 residues), 111.4 bits, see alignment E=5.5e-36

Best Hits

Swiss-Prot: 100% identical to SYV_METMP: Valine--tRNA ligase (valS) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01873, valyl-tRNA synthetase [EC: 6.1.1.9] (inferred from 100% identity to mmp:MMP0584)

Predicted SEED Role

"Valyl-tRNA synthetase (EC 6.1.1.9)" (EC 6.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZP0 at UniProt or InterPro

Protein Sequence (886 amino acids)

>MMP_RS03075 valine--tRNA ligase (Methanococcus maripaludis S2)
MEIKEEYSIELEKKVQEKWEDEKTFKFLDDEKRPPYIIDTPPPYPTGRMHLGHGLNWTYM
DIIARFKRMNGYDVLFPQGWDCHGLPTEVKVEELNNITKSDIDRHEFRRLCVELTDENVE
KMRGQVRSLGISIDWDREYITMNPDYVRKSQTAFLKMYEKGLIYRGKHPVNWCPRCETAI
AFAEVEYQGRTSKLNYIKFPYAENSGKYLEIATSRPELMAACVGIVVHPEDERYSDVVGK
TVKVPLFDQEVNVYPDSDVEKEFGTGVVMVCTFGDKTDVTWVNRHKLEVKKAINEKGQLT
EICGKYAGKKSDDARKEIISDLISENYMIKQEPLEQNVGSCWRCKTPIEIIVGDQWFVNV
TKLLTEVENAANEISWVPEHMKARLMKWIEDMGWDWCISRQRLFATPIPVWYCKDCGEII
VAKPEDLPIDPTKESPYTCKCGNSNLVAETDVLDTWMDSSITPLVIAGWLEDEEFFKKHY
PVQLRPQGHDIIRTWAFYTMVRSLAITGEKPWDEIVINGMVFGEDGFKMSKSRGNVVEPG
EITKTYGADALRLWASNSTIGKDVPFAWKEVEYGGRFLRKIWNACKFAKMNISDETISEL
KSLNSISIENPVDLWILSKLNNLISKVSDDLGNYKINTVVEIQKFLWHEFCDNYIEMVKH
RLYNKEESESAQQEKLMAQYTLYKVITESVKLLTPFTPHFAEIVGEIYEIDDLHTSWPVS
DERLISLENEFVGEVVKNTVASIRRYKSNKGMPLNAELNKVEMYVSDEKDFNAVSKASED
VKKSLKIKELEINLGKPSLEQKISEVTPNKSKIGPEFKKDAGKVMAFIKEADADTIEKML
SEGIETEFGILNKEHIKEVKRAIYNKGEIVETADIDSLIDTIAIIQ