Protein Info for MMP_RS02895 in Methanococcus maripaludis S2

Annotation: DHH family phosphoesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 431 PF01368: DHH" amino acids 30 to 147 (118 residues), 35.8 bits, see alignment E=8.9e-13 PF02272: DHHA1" amino acids 355 to 426 (72 residues), 35.6 bits, see alignment E=1.1e-12

Best Hits

Swiss-Prot: 53% identical to Y831_METJA: Uncharacterized protein MJ0831 (MJ0831) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07463, archaea-specific RecJ-like exonuclease (inferred from 100% identity to mmp:MMP0547)

Predicted SEED Role

"Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-)" in subsystem DNA-replication or DNA Repair Base Excision or DNA repair, bacterial RecFOR pathway (EC 3.1.-.-)

Isozymes

Compare fitness of predicted isozymes for: 3.1.-.-

Use Curated BLAST to search for 3.1.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZS6 at UniProt or InterPro

Protein Sequence (431 amino acids)

>MMP_RS02895 DHH family phosphoesterase (Methanococcus maripaludis S2)
MDILPIEDISKFNQITGKIKEKIENCDGLIRIVTHHDPDGLTAGSIMLKTLLRLNKNVQM
TILEHLSKESVEELSKENDKMFIFCDMGSGQINLINHLQFNAVILDHHPPEVAETEIGNI
LQLNPHLFGANGAKEISASGVCYLIARLFEYYDLATVAVVGAIGDMQHLPFIGLNKYILN
EARKYRYLSVIKDIVYNCYNLPISRSIYYSTQPYIRELDGIDKIKEILEELSINPEKKGI
TVAEKENLLEYFKRFNKNDDLIVDRYEINHKLNDAFYLSEVLNACGRKEMTSVGIGILLG
DDECIRQGENLYKEYKDELIGELKNVKLTSMDNIEYFIGEKGKTGIISALMVKDKPVLGF
NEQGEIYKVSSRGSKELVECGLNLSKAMVVSKEFGGDGGGHNIASGAAIQKNYLNEFLEK
VNEIVGEQLKK