Protein Info for MMP_RS02750 in Methanococcus maripaludis S2

Annotation: HAD-IC family P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 834 transmembrane" amino acids 43 to 65 (23 residues), see Phobius details amino acids 71 to 88 (18 residues), see Phobius details amino acids 234 to 253 (20 residues), see Phobius details amino acids 265 to 291 (27 residues), see Phobius details amino acids 629 to 649 (21 residues), see Phobius details amino acids 655 to 676 (22 residues), see Phobius details amino acids 697 to 723 (27 residues), see Phobius details amino acids 734 to 752 (19 residues), see Phobius details amino acids 772 to 791 (20 residues), see Phobius details amino acids 806 to 826 (21 residues), see Phobius details PF00690: Cation_ATPase_N" amino acids 13 to 61 (49 residues), 39.8 bits, see alignment 8.7e-14 TIGR01494: HAD ATPase, P-type, family IC" amino acids 74 to 514 (441 residues), 178.8 bits, see alignment E=7.1e-57 amino acids 542 to 656 (115 residues), 104.1 bits, see alignment E=3.2e-34 PF00122: E1-E2_ATPase" amino acids 101 to 294 (194 residues), 171.4 bits, see alignment E=4.3e-54 PF00702: Hydrolase" amino acids 311 to 583 (273 residues), 68.2 bits, see alignment E=4.1e-22 PF13246: Cation_ATPase" amino acids 356 to 420 (65 residues), 26 bits, see alignment 2.3e-09 PF08282: Hydrolase_3" amino acids 564 to 614 (51 residues), 21.7 bits, see alignment 4.5e-08 PF00689: Cation_ATPase_C" amino acids 653 to 827 (175 residues), 125.5 bits, see alignment E=6.1e-40

Best Hits

KEGG orthology group: K01537, Ca2+-transporting ATPase [EC: 3.6.3.8] (inferred from 100% identity to mmp:MMP0520)

Predicted SEED Role

"Cadmium-transporting ATPase (EC 3.6.3.3)" in subsystem Cobalt-zinc-cadmium resistance (EC 3.6.3.3)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZV3 at UniProt or InterPro

Protein Sequence (834 amino acids)

>MMP_RS02750 HAD-IC family P-type ATPase (Methanococcus maripaludis S2)
MTFFKGFKEDYFGLTDLEVKQYRETYGKNELLQKKKKTLLSRILKILTEPMFVLLFIAAF
IYFFLGEPRDGSIMVISVIFICAIEFFQEWRTDRTLQALKELSSPKSTVIRNGKMMTIDS
TELIVNDLLILKEGEKIAADGIIVENYGLGVNESTLTGESDVVWKKIDLKEDETLEHWKK
NICYAGTSVTQGRAVVKVIHIGSETEYGKIGKDIFSVESMPTPLEKQTEKLVKYSAIAAF
FMLLLIVLVNFYYRGSVTDSILSGVTVAMAIIPEEFPVILTVFLAMGAWRLANKNSLIRR
IPAVETLGSISLLCVDKTGTLTKNQMEVKETYFDSKFNETELMTYACLASETEAYDPMEK
AIMIYSKSIRINIDELCTGCLLHEYPFSSETRMMGNVWNKDNKKFIALKGSFENIINLCD
LKESEKVNLEKKSIEMAKKGYRVIAVAKKMDVVTINQHLDEYTFEFVGLIGLMDPPREGV
SKAMKICNNAGIRVVMLTGDNGTTAKSIAKTIGLKNSENVLTGNEIDSMGDEELLEKINV
TNIFSRVIPKHKLRIIKAFKKLGEIVAMTGDGVNDAPALKYADIGVAMGKRGTEVAKEAS
DMILLDDNFETIVETIHDGRRIYDNIKKAIGYVFVIHIPVFLTALFAPLLKLPLLLLPIN
VVLMEFIIDPTCSIVFERQPAEKNIMLRKPRMPTEPLLDYSLIFKAIIQGVTIFAFAFGS
YVYLLYQGLEVNTARTFAFVILIAANFFLVYVNQSEIESVFSAFKKFKNDMLLWLVNIGI
FGGILIMLYVPSATEIAKTVPLTEKQLLSAILISGVSTLWWEVVKLLKRIKMKK