Protein Info for MMP_RS02625 in Methanococcus maripaludis S2

Annotation: ribonuclease H-like domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 364 transmembrane" amino acids 194 to 216 (23 residues), see Phobius details PF13482: RNase_H_2" amino acids 194 to 360 (167 residues), 134 bits, see alignment E=2.6e-43

Best Hits

KEGG orthology group: K07502, hypothetical protein (inferred from 100% identity to mmp:MMP0495)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZX8 at UniProt or InterPro

Protein Sequence (364 amino acids)

>MMP_RS02625 ribonuclease H-like domain-containing protein (Methanococcus maripaludis S2)
MKINLNLKDKISGIAQAFKKKSEDTTASKPVVDSVESTYGSNQVFRSPFFDEERQRALEL
QSKLLKKYSGVHLDDYFKGRVIKSEYGSSYCIEDEFKCKIKRNDIEKVKNCILSDLQLIR
GIGEKTELSLKNSGYNTICDLTKHNRYGSCAKEILTSLENNGVSGLLDSIPNNYPKSHPT
IMEASKMHKLEDFVFYDIETMGLFGSPIILFGMSFVADNKINTKQFLLRNINEEPSSLYH
TISELKTRKALVTFNGKSFDMPFTQDRLGYYRMNNSGIPQIHYDLLHFSRRAWGNNLENC
KLQTIEKELLGESRKDDVPSSMVPEFYRNYLRSGNIGPLVPIVEHNKIDVVTSAKILNLL
WEEW