Protein Info for MMP_RS02615 in Methanococcus maripaludis S2
Annotation: cobaltochelatase subunit CobN
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K02230, cobaltochelatase CobN [EC: 6.6.1.2] (inferred from 87% identity to mmq:MmarC5_1481)Predicted SEED Role
"CobN component of cobalt chelatase involved in B12 biosynthesis" in subsystem Coenzyme B12 biosynthesis
MetaCyc Pathways
- cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (10/13 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (24/33 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.6.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LZY0 at UniProt or InterPro
Protein Sequence (2062 amino acids)
>MMP_RS02615 cobaltochelatase subunit CobN (Methanococcus maripaludis S2) MLSSLITSVSAEEIDYKFISNTTSDGTGNFSFSNVPNGNYTLSGVIWSTAMGGMWLTNVQ EIEIENGSPVGNLSMAMRSNSSNDAEAILRMLNRTGVSGATVDKYGAPKTGVTLVLTDKN GDFVTNTTSDVTGNFSIGNIQNGNYTLSGVIWSTAMGGMWLTNVQEIEIENGSPVGNLSM AMRSNSSNDAEAILRMLNRTGVSGATVDKYGAPKTGVTLVLTDKNGDFVTNTTSDVTGNF SIGNIQNGNYTLSGVIWSTAMGGMWLTNVQEIEIENGSPVGNLSMAMRSNSSNDAEAILR MLNRTGVSGATVDKYGAPKTGVTLVLTKKIIVSTEDEEVSEPVEVGLVAETWYKFISNTT SDATGNFSFSNVPNGNYTLSGVIWSTAMGGMWLTNVQEIEIENGSPVGNLSMAMRKNDNN DAEAILRMLNRTGISGATVSKTGDPKVGTKLVLTDKNGDFVTNTTSDATGNFSIENLQNG NYTLSGVIWSTAMGGMWLTNVQEIEIENGSPVGNLSMAMRKNDNNDAEAILRMLNRTGIS GATVSKTGDPKVGTKLVLTDKNGDFVTNTTSDATGNFSIENLQNGNYTLSGVIWSTAMGG MWLTNVQEIEIENGIPVGNLSMAMRSNSSNDAEAILRMLNRTCISGATVSKTGDPKVGTK LVLTKKMVSYIPGEVSKLNVAIVTGYSNYEKQLSTSTDRINTDSDLNIVASYYTTSNLSA DIDLSQMDIIYIVMVTQSAEPIENTIQDAIDNGAVVIGSNTYLPESNYSIPEEHADIESF KKYLSEYWSGGASDDENFDNLIFYLAREYYNRTDLTVKEPTGLQRAIYHPNMTSTPIEFF TGDAGEYFAWYSNRTDGHSFDENAPTVGIAFYTSYYPNEMDPIDKLIAGFESKGVNVIAC YGDADNQLDGFFNYNNNTKVDAVISFLYRGTYFNMEELGVPVIDGVLNGYMNTSEWIETS NPLPVTNMLRIYRPESEGLIDPIMIGAEETVLEDNDTISKYMGHDTQIEWLINRTIAQCN LGIDPENEKKVAIIYYNHEGGKNNIGASYLEVAPSIVNLLNAMDSDGYNINESIIPNKTE LVDLILLQGRNIGSWAPGELESLVETGEVELIPEETYISWFNELPEERRNEVVETWGEAP GELMVYEYSNGSKYIVIPKISMSDNVIVAPQPSRGWMDSYDTLYHDTELPPNHQYIAFYL WLQKEFDADVMVNMGRHGTVEWLPGKEFCLLSDEWPALMVGDIPVVYPYVMDGTGEGMQA KRRGSAIIIDHLIPPVVSAGLYGNYSLLNSEIASYQTSVTESESLKQAQFEEIVNLTFEL GLENRVNMSLSENNGTIDEFLDELDDVLRDLRTLSMPYGLHVLGEAPDDDELVGMVNSML GSSYSEKVAAYNSSDSAANDLLTKVLLENITIDDAQMQVLGTTSEDIETDLQLAITYSEL LLEADDEIEQVLKAMNGEYIEPGLGGDPILRPETLPSGSNFYAFDEQLVPTKQAWEEGKA LVDEWLSQYYDENGEYPTKVAYILWAGESTRHQGIMEAQILYMLGVKPVWNENNGKVTDV EIINSSELNRPRIDVVVQISGLYRDSFPMKVQLIDKAVRLAYEEDEPDNYVRINTDELKD VLNEHLQNESLSLDIAQFRLFGPADGNYGTGMANAVSSSETWNDTDALAELYISRMSYIY GQNIWGQTISEYIELQTGQNVEINNTIIFENNINDVSDIFHSRSSNTYGSLDTNDFFQYV GGLINAITYESGESPDAHVVNLQNADDQKIESLQTYLENELYSRYYNPTWITGMQESGFE GATEMEKFVENLWGWEALTSDIISDGMWNKVYDTYVTDSELSAWLNENNPYAYQSMTARM LETARKGCWDASGETLKNLANEFIQSVAEYGVTCCHHTCGNLELNDWALEHSSLDEKTLK EYEKLYEEATQEDIEVPSQENKDTYTDSSSEPDSYSRVYSEEESKQEVLSNETVKTNTTT KEDSAASAGSDGADSNSGSSSTDSSDAPNSQKAYEIEVNEPENSGSSGTTMFAILGAVGM TGLIGFGYFRQNPNFLKFLRRK