Protein Info for MMP_RS02500 in Methanococcus maripaludis S2

Annotation: minichromosome maintenance protein MCM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 674 PF17207: MCM_OB" amino acids 103 to 221 (119 residues), 58.3 bits, see alignment E=1.7e-19 PF00493: MCM" amino acids 259 to 477 (219 residues), 236.5 bits, see alignment E=5.2e-74 PF07728: AAA_5" amino acids 311 to 432 (122 residues), 25.1 bits, see alignment E=4e-09 PF01078: Mg_chelatase" amino acids 360 to 459 (100 residues), 27.6 bits, see alignment E=4.7e-10 PF17855: MCM_lid" amino acids 505 to 581 (77 residues), 85.4 bits, see alignment E=7.6e-28

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0470)

Predicted SEED Role

"DNA replication helicase protein MCM" in subsystem DNA replication, archaeal

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M003 at UniProt or InterPro

Protein Sequence (674 amino acids)

>MMP_RS02500 minichromosome maintenance protein MCM (Methanococcus maripaludis S2)
LDDKKIADLRPKITDYLKENYSEDMLKESERVAVDLNGMYHYGMFEFIEFIESDPKEAIN
LLKECYYDAYHVYKGERADCTVTIKNLPLMINKNSRGNERTIEDIKGKTHGKLVEIEGII
VMATKIKLALKEAVHICTACGEKRRTKIERPFQANFDPVCPKCAQNMTLLEDESEYVDFQ
ELKIQQPLDLMEDPEEPPKFISVLLEDTQGIYCGRVKVTGIPIKNQKNKNIPLHDLLILG
YNCEPISEKLDVSFNDEEIEQFETLAKNKDVLKILSRRIAPQIKGNDIIKQSIVLQQVRG
VKKGRKRADSHILLITDPGTGKSDVLRFISGIPGNVYSSISTASGVGLTAGVVQERTEIG
DSTWVIKPGVLVKANGGTACLDELTVERSVLSYILEAMESQTIHISKGGLNTKLPAGCSI
LAACNPKYGRYNEHVAVIEQINIPAPLLSRFDLIFPIKDTPNRNRDSDIAYHILDTHIAL
MDKSKNEEIGLFSETIGELKVDFDFFCKYIAYARQKTPKFTKESKEVIHDFYLNLRKTSV
QITARQLEALVRLSEAHAKVRLKSEVEPEDAKFAIYLMIESLKEVAYDHETDSFDIDKIF
GTSRNERSKLNIIFDIIRRSSKVAYGGTVSRGDLLTEAQLEGIPELEVIDLIGKLKVIGD
IYEPKIGFYKDARA