Protein Info for MMP_RS02095 in Methanococcus maripaludis S2
Annotation: phosphoribosylamine--glycine ligase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to PUR2_METMP: Phosphoribosylamine--glycine ligase (purD) from Methanococcus maripaludis (strain S2 / LL)
KEGG orthology group: K01945, phosphoribosylamine--glycine ligase [EC: 6.3.4.13] (inferred from 100% identity to mmp:MMP0392)Predicted SEED Role
"Phosphoribosylamine--glycine ligase (EC 6.3.4.13)" in subsystem De Novo Purine Biosynthesis (EC 6.3.4.13)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (35/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (17/21 steps found)
- superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
- 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (17/26 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.4.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M079 at UniProt or InterPro
Protein Sequence (444 amino acids)
>MMP_RS02095 phosphoribosylamine--glycine ligase (Methanococcus maripaludis S2) MKVLLIGGGAREHAIAMALKKNELVELYTLMKNKNPGIYALSEEVSFNSETDVPAIKEFA EKIKPEIAVIGPESPLGVGASDLLEEMGIPTVGPKKLPAQIETSKEFMRNLFKKYEIDGS LKYAAFNDYGTELEGFIDEMTSLGKDVVVKPAGLTGGKGVKVVGEQLKDNEEAKIYAKEV FDKSIGGGKIIIEEKLVGVEFTLHGFVDGENIVFMPAVQDHPHAYNNDEGPITGGMGSYS CPNHGLPFLSEEMLDKAEKIMEKTVNSINLEVGPYKGFLYGQFMLTADGPKIIEYNARFG DPEAMNLLPILKTDFLDVCFAIAEGKLDKINIEFENKATVCKYVVPNGYPIDPVRNKELA VDEKAIEDANAILFYASINEENGKLYITGSRSAAVVGISENIEEAEKIAQKAIENFKGEV YYRSDIGTLDLIKKRVERVKKLAK