Protein Info for MMP_RS02075 in Methanococcus maripaludis S2

Annotation: NAD(P)/FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 390 TIGR02032: geranylgeranyl reductase family" amino acids 8 to 305 (298 residues), 223.6 bits, see alignment E=2.2e-70 PF05834: Lycopene_cycl" amino acids 9 to 159 (151 residues), 23.5 bits, see alignment E=1.3e-08 PF01134: GIDA" amino acids 9 to 44 (36 residues), 26.2 bits, see alignment 1.9e-09 PF12831: FAD_oxidored" amino acids 9 to 43 (35 residues), 35 bits, see alignment 4.8e-12 PF00890: FAD_binding_2" amino acids 9 to 49 (41 residues), 28.5 bits, see alignment 4.1e-10 PF13450: NAD_binding_8" amino acids 12 to 49 (38 residues), 25.2 bits, see alignment 7.3e-09 PF22578: GGR_cat" amino acids 175 to 245 (71 residues), 67.5 bits, see alignment E=3.4e-22

Best Hits

Swiss-Prot: 100% identical to GGR_METMP: Digeranylgeranylglycerophospholipid reductase (MMP0388) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0388)

MetaCyc: 41% identical to 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase (Archaeoglobus fulgidus)
RXN-14399 [EC: 1.3.7.11]

Predicted SEED Role

"Digeranylgeranylglycerophospholipid reductase" in subsystem Archaeal lipids

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.7.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M083 at UniProt or InterPro

Protein Sequence (390 amino acids)

>MMP_RS02075 NAD(P)/FAD-dependent oxidoreductase (Methanococcus maripaludis S2)
MKALNDSYDVVVVGAGPAGSMASYNASKNGAKTLLIEKSQEIGTPVRCAEAVPRLEDFGI
NPDPSFVKSYIRGGYLIAPNGKKIVVKGGKTDGYVVERKVFDKFLAIRSGQAGTQIAVKS
RVTKIEKTDDGYNVFVNYLGDEYIVKSKIVIAADGVESNIAEYAGLKSKKNPKEICSCAE
YEMTNVKLLNNEMMEFYFGDICPKGYIWLFPKGDTVNVGIGVIDSKKRAIDYLDEFLTHP
LVEGRLDNAVPVEFKVGGDPVGGPIKKTVADNIMVVGDAAGHVSPLTGGGIGLSMDCGLM
AGDVAAQSIKAENYSEEFLDLYEKKWKEKYYKLLMNDLKYKNILQKLSDDELNAIANSIP
ENLEEVDVGKLAIKIVAKAPSLLRHFKELL