Protein Info for MMP_RS01885 in Methanococcus maripaludis S2

Annotation: Gfo/Idh/MocA family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 311 PF01408: GFO_IDH_MocA" amino acids 2 to 122 (121 residues), 104.4 bits, see alignment E=9.8e-34 PF22725: GFO_IDH_MocA_C3" amino acids 131 to 241 (111 residues), 69.5 bits, see alignment E=4.2e-23 PF02894: GFO_IDH_MocA_C" amino acids 134 to 309 (176 residues), 55.6 bits, see alignment E=9.8e-19

Best Hits

Swiss-Prot: 100% identical to UGNO_METMP: UDP-N-acetylglucosamine 3-dehydrogenase (MMP0352) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0352)

Predicted SEED Role

"NAD-dependent dehydrogenase (EC 1.1.1.18)" (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0B9 at UniProt or InterPro

Protein Sequence (311 amino acids)

>MMP_RS01885 Gfo/Idh/MocA family oxidoreductase (Methanococcus maripaludis S2)
MLKVAVVGIGVMGYNHARIYNELQKDGNVELVGLSDMNKDRLNEVSEEFGVKAFSNYMDL
LEEDLDAVSIVVPTFLHKEVALPFIKKGISVLIEKPIADTIENANEIIAEAEKNNVILSV
GHVERFNPAVLKLKEHVEKGNLGDIVTMTAKRVGPMTTRIADAGVILDLAVHDIDVMAFL
ANSKVKHVHALAKNVKHPNNNAEDYALIISSFENSIDGIIEVNRLTPHKTRTLNIVGTKG
IAYLDYMNQDLTLYDEEWVKTAKINKEEPLKKEIAHFVDCVQNNKQPLVTGLDGLNALET
AIYALKSSNGN