Protein Info for MMP_RS01555 in Methanococcus maripaludis S2

Annotation: hydrogenase formation protein HypD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 360 TIGR00075: hydrogenase expression/formation protein HypD" amino acids 5 to 359 (355 residues), 527.6 bits, see alignment E=7.9e-163 PF01924: HypD" amino acids 13 to 356 (344 residues), 476.5 bits, see alignment E=2.7e-147

Best Hits

Swiss-Prot: 72% identical to Y993_METJA: Putative hydrogenase expression/formation protein MJ0993 (MJ0993) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K04654, hydrogenase expression/formation protein HypD (inferred from 100% identity to mmp:MMP0289)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypD" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0I1 at UniProt or InterPro

Protein Sequence (360 amino acids)

>MMP_RS01555 hydrogenase formation protein HypD (Methanococcus maripaludis S2)
MDAKIMNINNKELIKKSIQTIQKLSEKLDEVKIMHVCGSHEHTICKYGIRDVLPDNITVV
PGPGCPVCVTTQKEIDKAMYLAEQGYTIATLGDMYRVPGSKKSLMQLQSEGADVKIVYGI
GDAVKLAKKQDEKVVFVAIGFETTAPTTAAELLNKPENFYILNSHRQTPPVMGFLLGGGT
SLNLDGFICPGHVSTITGLKPYYDPCKTYHAPMVVAGFEPIDVMASIVMILKQLVNGEAK
VENEYTRGVREEGNVIAQKIMNKVFEPADVAWRGFPVIKDGGMKLREEFKKYDVHENIDV
PDIKETINKACICSEILRGEKLPHDCKLFGKTCDPMNPVGSCMVSDEGTCRIFYKYSKFR