Protein Info for MMP_RS01480 in Methanococcus maripaludis S2

Annotation: hydrogenase expression/formation protein HypE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 TIGR02124: hydrogenase expression/formation protein HypE" amino acids 3 to 334 (332 residues), 387.3 bits, see alignment E=2.7e-120 PF00586: AIRS" amino acids 41 to 150 (110 residues), 96.3 bits, see alignment E=1.6e-31 PF02769: AIRS_C" amino acids 162 to 312 (151 residues), 117 bits, see alignment E=9.2e-38

Best Hits

Swiss-Prot: 76% identical to Y676_METJA: Putative hydrogenase expression/formation protein MJ0676 (MJ0676) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K04655, hydrogenase expression/formation protein HypE (inferred from 100% identity to mmp:MMP0274)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypE" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0J6 at UniProt or InterPro

Protein Sequence (334 amino acids)

>MMP_RS01480 hydrogenase expression/formation protein HypE (Methanococcus maripaludis S2)
MNITRMHGAGGTVMQKLIKETILGNLENTKIEGGIGLESLDDASTIPIGDKEIVFTVDGH
TVHPIFFPGGDIGRISVCGTVNDLSVMGAKPVALSLSIVLPEGFDIEKLDKIMKSINEAC
KEAGVAIITGDTKVSNVDDIIISSAGIGIVDSGKAVRDCGMKEGDVIIVSGNIGEHGLTI
LLSREGFEFESELKSDVAPVNGLVQSVLNAGFEINAMKDPTRGGLADSLNEMAEKSDLGI
LIHEDKIPISDEVQAIGEALGIDPLTVANEGKVVMSVKEKDSEKILEILTAHPLGKNAKI
IGNVTSEHKGVLMETIVGKRIVDTPMGDPIPRVC