Protein Info for MMP_RS01190 in Methanococcus maripaludis S2

Annotation: cadmium-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 691 transmembrane" amino acids 82 to 101 (20 residues), see Phobius details amino acids 107 to 124 (18 residues), see Phobius details amino acids 136 to 154 (19 residues), see Phobius details amino acids 160 to 177 (18 residues), see Phobius details amino acids 309 to 329 (21 residues), see Phobius details amino acids 340 to 362 (23 residues), see Phobius details amino acids 643 to 663 (21 residues), see Phobius details amino acids 669 to 689 (21 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 140 to 688 (549 residues), 546.6 bits, see alignment E=1.2e-167 TIGR01512: cadmium-translocating P-type ATPase" amino acids 140 to 691 (552 residues), 497.9 bits, see alignment E=4.7e-153 TIGR01494: HAD ATPase, P-type, family IC" amino acids 163 to 663 (501 residues), 255.3 bits, see alignment E=1.4e-79 PF00122: E1-E2_ATPase" amino acids 191 to 369 (179 residues), 166.2 bits, see alignment E=5.9e-53 PF00702: Hydrolase" amino acids 389 to 600 (212 residues), 96.3 bits, see alignment E=3.1e-31

Best Hits

Swiss-Prot: 42% identical to HMCT_HELPY: Cadmium, zinc and cobalt-transporting ATPase (cadA) from Helicobacter pylori (strain ATCC 700392 / 26695)

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to mmp:MMP0216)

Predicted SEED Role

"Cadmium-transporting ATPase (EC 3.6.3.3)" in subsystem Cobalt-zinc-cadmium resistance (EC 3.6.3.3)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0Q3 at UniProt or InterPro

Protein Sequence (691 amino acids)

>MMP_RS01190 cadmium-translocating P-type ATPase (Methanococcus maripaludis S2)
MQKYILKGLCCAGCASKIEKLLKEQGYPSAVINMATSELILDEKEIDLEKITKIVTSIEP
GVIVIPKQSEIKITNEIDYNELKKIVISSVFFILGIFSSHFGYSLSIQLLFFIVSYILVG
QKVLKKTFQNIKRLDFFDENFLMSIATIGAFLIGEYPEGVAVMLFYSIGEFFQNIAVTRS
RNSIKSLVSIKAEYANVLENGETIKVKPENVQIGQTIIIKPGEKVPIDGIVLNGKSSLDT
SALTGESTPKSINRDEEVLSGMINLSGLLTVQTTKNFSDSAVSKILNLVESASINKTKTE
KFITKFAKVYTPIIVFIAVLLAVVPPIIFNEPFVPWFYKALILLVISCPCALVLSIPLGY
FAGIGRLAKEGILVKGSNYIDVLSKTTYVSFDKTGTLTEGKFKVTKVVSKNEFSGKKLLE
IAKMVECNSNHPIAKTIMDFGTISCKTSLDDFEEFSEVLGKGIISRINGSEIIAGNEKLM
EEKNINFEKLDVYETAVHFAVDGVYAGYILISDKLKKDSKETVLELKKLGIKKVSMLTGD
KKDIAEKIASELNLDEYYSDLLPEDKVKIIEEIEANKSKKETIAFVGEGINDAPVIARAD
VGISMGTLGSDAAIETADVVIMNDKPSKLISAIKISKRTQNIAFQNIFVILIVKIAFISL
GIFGETTMWQAVFADVGVALLSVLNAVRILK