Protein Info for MMP_RS01000 in Methanococcus maripaludis S2

Annotation: AIR synthase related protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 989 transmembrane" amino acids 882 to 893 (12 residues), see Phobius details PF18072: FGAR-AT_linker" amino acids 211 to 253 (43 residues), 53.6 bits, see alignment (E = 4e-18) PF00586: AIRS" amino acids 302 to 425 (124 residues), 31.5 bits, see alignment E=3.2e-11 amino acids 681 to 779 (99 residues), 24.4 bits, see alignment E=5.1e-09 PF02769: AIRS_C" amino acids 442 to 593 (152 residues), 98.7 bits, see alignment E=5.7e-32 amino acids 824 to 960 (137 residues), 59.9 bits, see alignment E=5.1e-20

Best Hits

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 100% identity to mmp:MMP0179)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0T9 at UniProt or InterPro

Protein Sequence (989 amino acids)

>MMP_RS01000 AIR synthase related protein (Methanococcus maripaludis S2)
MQTINAENNGKIYRIEIDTKEKSSEAKVIEKKLFELGYDVSVDVSKVYTINYDFSIANVE
KIANSLHNPVTEMPRINVPSNNKFDWALELGFLPGVTDNVANTTTEIINDLLKIDIGLSK
VFSSKVVYLSGNLAKHDVEKIAEELINILIERYHIKTYDNYVKGCGMDYIIPKVNLTSEP
KVIEISLNVSDDELIEIGKKGILDPETGERRGPLALDLDYITAIKEYYQKEGRNPTDIEL
EALAQTWSEHCKHTIFASQIDDIEEGIFKKYIRNATNEIREELGEKDFCISVFSDNSGGI
IFDDEWMVTDKAETHNSPSALDPFGGAITGIVGVNRDTVGFGLGALPVANKYGFCVGRPE
DTEIIYRGQNKTNPSLLPRRILDGIVHGVNVGGNQSGIPTPNGFVYFDDTYKGKPLVFVG
TIGLIPRKLPDGRLSHEKAAENGDNIVIIGGRVGKDGIHGATFSSEAMDEGSPAAAVQIG
DPITQKKLSDAVIKEARDKGLYNSITDNGAGGISCSVAEMAEECGGFVVELEEVPLKYPG
LEPWEIWISESQERVTLSVPDDKLEEFMDLMKIRGVEAVVIGKFNNTDRAVVNYNGKTIM
DLEMDFLHNGLPKRKLITKPYSYRTEEPEITVENQLETFEKILGNHNNCSFEYISKQYDH
EVQNNSVIKPLQGKGRVNGTASVIRPLLSSQKGLVMSQSLLPRLSEISCYDMAACAMDTA
IRNCVAVGGNINHIAIMDNFCWCSSDEPERLYQLKDAAKSCYDYAKTYLTPLISGKDSMF
NDFKGFDENNNPIKISVHPTLMMSALGVIDNIEHTNSMDLKLKDDLIYVIGETKDECGGS
EFYHAFGEVGGISPKVDAKSARKLYEKMYELSQKGIFSSCASVAAGGLVITLAKMAISGC
LGLEADLSKAPNENISFEKIMYSETQSRFIVTIAPENEKEFENLMKEFKIGKIGNVTEKD
FVIKNNKDIVITSSLESMDEVYRSRFEDF