Protein Info for MMP_RS00785 in Methanococcus maripaludis S2

Annotation: deoxyhypusine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00321: deoxyhypusine synthase
  • amino acids 20 to 335 (316 residues), 417.7 bits, E=1.4e-129
• PF01916: DS
  • amino acids 35 to 331 (297 residues), 381.5 bits, E=1.3e-118

Best Hits

Swiss-Prot: 87% identical to DHYS_METVS: Probable deoxyhypusine synthase (dys) from Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)

KEGG orthology group: K00809, deoxyhypusine synthase [EC: 2.5.1.46] (inferred from 100% identity to mmp:MMP0137)

Predicted SEED Role

"Deoxyhypusine synthase (EC 2.5.1.46)" (EC 2.5.1.46)

MetaCyc Pathways

• hypusine biosynthesis (4/5 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.46

Sequence Analysis Tools

See Q6M0Y1 at UniProt or InterPro

Protein Sequence (335 amino acids)

>MMP_RS00785 deoxyhypusine synthase (Methanococcus maripaludis S2)
MSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWKQIE
EVRKNEEVVVFMGYTSNMVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPFVLG
EWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKFFETLLKKQQDENKIISASEFCFE
LGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKIDVAS
DIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSGAPP
EEGVSWGKIQEKADFVEIWADATIVFPMLVYGVFK