Protein Info for MMP_RS00495 in Methanococcus maripaludis S2
Annotation: hydroxymethylglutaryl-CoA reductase (NADPH)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 75% identical to HMDH_METJA: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmgA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
KEGG orthology group: K00021, hydroxymethylglutaryl-CoA reductase (NADPH) [EC: 1.1.1.34] (inferred from 100% identity to mmp:MMP0087)MetaCyc: 80% identical to hydroxymethylglutaryl-CoA reductase monomer (Methanothermococcus thermolithotrophicus)
Hydroxymethylglutaryl-CoA reductase (NADPH). [EC: 1.1.1.34]
Predicted SEED Role
"Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.1.1.34)
MetaCyc Pathways
- superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (8/10 steps found)
- mevalonate pathway I (eukaryotes and bacteria) (5/7 steps found)
- mevalonate pathway II (haloarchaea) (5/7 steps found)
- isoprene biosynthesis II (engineered) (5/8 steps found)
- mevalonate pathway IV (archaea) (5/8 steps found)
- mevalonate pathway III (Thermoplasma) (4/8 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (35/56 steps found)
- superpathway of ergosterol biosynthesis I (7/26 steps found)
- superpathway of cholesterol biosynthesis (7/38 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Terpenoid biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.34
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M131 at UniProt or InterPro
Protein Sequence (408 amino acids)
>MMP_RS00495 hydroxymethylglutaryl-CoA reductase (NADPH) (Methanococcus maripaludis S2) MENNVNIDEIVEKLLKKEIKVYQLDSKFGERNAVIARRKYVEKLSNVETRHIQEYTLDEK LAMQKNIENMIGAVQIPLGFAGPISINGKYAQGEFNVPLATTEGALVASINRGCSIITKC GGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILDNFAKIKEIAESTTRHGKLIQISPIL IVGRNVYPRFTFKTGDAMGMNMVTIATEKACSFIESELKKEGIIIDTVALSGNVCVDKKP AAINLIEGRGKSVVAEVFLKEEYVEKYLKTTSKAIEQVNTYKNLIGSAISSSLGFNAQYA NIVGALFLATGQDEAHIVEGSMGITTAECTGDGLYFSVTLPDLPVATIGGGTRVETQREC LEILGCAGAEKAVKFAEIAGAAVLAGELSLIGALAAGHLAKAHSELGR