Protein Info for MMP_RS00150 in Methanococcus maripaludis S2

Annotation: AAA family ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 PF23900: PRS2_N" amino acids 29 to 104 (76 residues), 101.2 bits, see alignment E=8.1e-33 PF05496: RuvB_N" amino acids 123 to 228 (106 residues), 31 bits, see alignment E=8.2e-11 PF06068: TIP49" amino acids 124 to 195 (72 residues), 30.6 bits, see alignment E=8.2e-11 PF01078: Mg_chelatase" amino acids 157 to 177 (21 residues), 20.3 bits, see alignment (E = 1.3e-07) PF07728: AAA_5" amino acids 158 to 280 (123 residues), 25.3 bits, see alignment E=5.4e-09 PF07724: AAA_2" amino acids 158 to 253 (96 residues), 33.6 bits, see alignment E=1.6e-11 PF00004: AAA" amino acids 159 to 287 (129 residues), 136.3 bits, see alignment E=3.5e-43 PF23902: AAA_lid_PRS2_C" amino acids 291 to 363 (73 residues), 150.9 bits, see alignment E=3.4e-48

Best Hits

Swiss-Prot: 65% identical to PRS2_METJA: Putative 26S proteasome regulatory subunit homolog MJ1494 (MJ1494) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07392, AAA family ATPase (inferred from 100% identity to mmp:MMP0024)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M193 at UniProt or InterPro

Protein Sequence (371 amino acids)

>MMP_RS00150 AAA family ATPase (Methanococcus maripaludis S2)
MSNINISNLKLKKTLQKPPVVPEEAMCLKYVILEPVGFPINVNGETLKVSVEDHALFNSY
AREQWENEIVKEGAYLFDSTIIPEYAFKVVSLYPKEGGIITKDTLFKLENNCKPQNSPKF
KETTFEEVVGQIDAKKKCKIVIKYLENPELFGEWAPKNILFYGPPGTGKTMLARALATET
DVPLYLIKATELIGDHVGDGSKQIESLYENASENTPSIIFIDELDAIALSRQFQSLRGDV
SEVVNALLTELDGIKNNLGVVTIAATNNPEMLDNAIRSRFEEEIEFKMPDDNERLKILEL
YAEKMPIAVNADLKKYVEKTKGMNGRTIKEKFLKPALHKAILEDRESITQKDLDEIIKKI
VKNSTPLNLYG