Protein Info for MMJJ_RS03080 in Methanococcus maripaludis JJ

Annotation: carbohydrate kinase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 6 to 288 (283 residues), 191.8 bits, E=9.4e-61

Best Hits

Swiss-Prot: 63% identical to NK_METJA: Nucleoside kinase (MJ0406) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00852, ribokinase [EC: 2.7.1.15] (inferred from 98% identity to mmp:MMP0418)

Predicted SEED Role

"Inosine-guanosine kinase (EC 2.7.1.73); Cytidine kinase" (EC 2.7.1.73)

MetaCyc Pathways

• superpathway of guanine and guanosine salvage (3/3 steps found)
• guanine and guanosine salvage III (1/1 steps found)
• adenine and adenosine salvage V (2/3 steps found)
• ribose phosphorylation (1/2 steps found)

KEGG Metabolic Maps

• Pentose phosphate pathway
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.15 or 2.7.1.73

Protein Sequence (302 amino acids)

>MMJJ_RS03080 carbohydrate kinase family protein (Methanococcus maripaludis JJ)
MDKIGKITAVGHIALDYIFNVDKFPELNTSMQIPTAKKYYGGAACNVAAEIANLGVKSEI
LSCVGTDFKASGYGEYLEKLGVSTKSVFVSEEEETPKAWIFTDPQNNQITYFLWGAAKHY
PEIEVPEFDSEIVHLATGDPNYNLKCAQKASSKGILVSFDPGQDLTLYSKENMENIIENV
DFLFMNNHEFQRTLDLLNISEKELISRVKVLIVTYGKQGSIIYSEDDAIKVPAVLTQAKD
PTGAGDSYRAGFLTAYLKGHDLKNCGLAGSCVASFVVEQVGCQTNLPSWDMVIERLNENN
LL