Protein Info for MMJJ_RS01810 in Methanococcus maripaludis JJ

Annotation: methyl coenzyme M reductase system, component A2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 531 TIGR03269: methyl coenzyme M reductase system, component A2" amino acids 4 to 530 (527 residues), 871.8 bits, see alignment E=8.2e-267 PF00005: ABC_tran" amino acids 19 to 197 (179 residues), 87 bits, see alignment E=2.7e-28 amino acids 302 to 456 (155 residues), 90.2 bits, see alignment E=2.8e-29

Best Hits

Swiss-Prot: 71% identical to Y1242_METJA: Uncharacterized ABC transporter ATP-binding protein MJ1242 (MJ1242) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00400, methyl coenzyme M reductase system, component A2 (inferred from 100% identity to mmp:MMP0620)

Predicted SEED Role

"Methyl coenzyme M reductase system component A2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (531 amino acids)

>MMJJ_RS01810 methyl coenzyme M reductase system, component A2 (Methanococcus maripaludis JJ)
MLLLEVKNVSKSYGDTEVLKNVSFELNEGDVMGVLGRSGAGKSVLLHMLRGMEGYEPTSG
QIIYHVAYCPHCENVEAPSQVGKKCECETEYVAKSVDFWNNNEITYALKKKIAIMLQRTF
ALYGEKTVAENIMEALTAAGYEGKDATEWALNLIKMVKLEHRVAHISRDLSGGEKQRVVL
ARQIAKNPVIFLADEPTGTLDPKTAKFVHNALTEAVIKHNIAMVITSHWPEVIEELCQKA
IWLDKGEMRLVGESKHVVEEFMKTVTSMKEFEKVEVKDELLKLENVEKRYVSVDRGIVKA
VDGIDVSINEKEIFGLVGVSGAGKTTLSKIIAAVIPPSKGNYEFRLADEWVDMTKVGPLY
RGRAKRYIGMLFQEYSLYPHRTILYNLTESIGLEMPGEFAKMKAEHTLVSVGFTEEEAEN
MLEKHPSELSVGEKHRVALAQVLIREPHLILLDEPTGTMDPITRNQVAESIQKSRSELDQ
TYVIVSHDMDFVLNVCDRAALVRGGKIIKTGKPDEIVKILSEEEKDEMIGH