Protein Info for MMJJ_RS01415 in Methanococcus maripaludis JJ

Annotation: beta-CASP ribonuclease aCPSF1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 PF17214: KH_TffA" amino acids 4 to 69 (66 residues), 81 bits, see alignment E=1.8e-26 TIGR03675: arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein" amino acids 8 to 634 (627 residues), 954.9 bits, see alignment E=8.8e-292 PF07650: KH_2" amino acids 83 to 127 (45 residues), 24.5 bits, see alignment 6.7e-09 PF00753: Lactamase_B" amino acids 199 to 372 (174 residues), 47.4 bits, see alignment E=8.1e-16 PF16661: Lactamase_B_6" amino acids 202 to 337 (136 residues), 42.5 bits, see alignment E=1.7e-14 PF12706: Lactamase_B_2" amino acids 204 to 354 (151 residues), 40.7 bits, see alignment E=7e-14 PF10996: Beta-Casp" amino acids 420 to 544 (125 residues), 117.9 bits, see alignment E=1.3e-37 PF07521: RMMBL" amino acids 563 to 626 (64 residues), 59 bits, see alignment E=1.3e-19

Best Hits

Swiss-Prot: 76% identical to Y1236_METJA: Uncharacterized protein MJ1236 (MJ1236) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07041, (no description) (inferred from 100% identity to mmp:MMP0694)

Predicted SEED Role

"Protein similar to polyadenylation specificity factor, MJ1236 type"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (635 amino acids)

>MMJJ_RS01415 beta-CASP ribonuclease aCPSF1 (Methanococcus maripaludis JJ)
MSAEDILNEIKAAVINKAPGNAVITDVEFEGSEVVIYAKNPELFSNNLIKEFARDFRKRL
AIRPDPSVLVEPDIAKDKILKIVPEDAEITNCIFDANTGEVIIESKKPGLVIGKEGSTLE
DIKKAIQWAPKPVRTPPIPSDTIKAIRATMYRERADVKDILRRIGRRIHRDVRLRDDSWV
RTSFLGGSREVGRTCLYHQTPESRILVDCGINIAVEDEKAFPHFDAPEFSIEEIDAVVVT
HAHLDHCGFIPGLFRYGYDGPVYCTKPTRDLMTLLQKDYVDITEKEGKNVPYSSKDIKNC
IKHTIPLDYGVTTDIAPAINLTMHNAGHILGSAIAHCHVGDGLYNVAYTGDIKFEASRLL
EPAVCQFPRLETLIIESTYGGYDDVLPERDETEKEFLRVIAETIARKGKAIIPVFGIGRA
QELMLVLEEGYNQGIFNAPVYLDGMIWEATAIHTAYPEYLSKNMRNRIFHEGDNPFLSEV
FKKVKNTNDRRNIMDSDEPGIILTTSGMLSGGPSVEYFKNLADDEKNSIVFVGYQSEGTL
GRKIQKGFKEIPLMGKNGRSKAVKVNLSVHTLEGFSGHSDRKQLIKYLRKLKPIPDRILT
VHGEVSKCIDLASTAYKLFKKETKAPMNLDSIRLR