Protein Info for MMJJ_RS01320 in Methanococcus maripaludis JJ

Annotation: indolepyruvate ferredoxin oxidoreductase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 578 TIGR03336: indolepyruvate ferredoxin oxidoreductase, alpha subunit" amino acids 1 to 573 (573 residues), 750.4 bits, see alignment E=6.3e-230 PF01855: POR_N" amino acids 14 to 189 (176 residues), 51.2 bits, see alignment E=4.3e-17 PF02775: TPP_enzyme_C" amino acids 360 to 504 (145 residues), 88.6 bits, see alignment E=1.1e-28 PF13237: Fer4_10" amino acids 524 to 568 (45 residues), 26.8 bits, see alignment 1.2e-09 PF00037: Fer4" amino acids 552 to 573 (22 residues), 22.6 bits, see alignment (E = 2.1e-08)

Best Hits

KEGG orthology group: K00179, indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC: 1.2.7.8] (inferred from 97% identity to mmp:MMP0713)

Predicted SEED Role

"Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8)" in subsystem Aromatic amino acid interconversions with aryl acids (EC 1.2.7.8)

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.8

Use Curated BLAST to search for 1.2.7.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (578 amino acids)

>MMJJ_RS01320 indolepyruvate ferredoxin oxidoreductase subunit alpha (Methanococcus maripaludis JJ)
MKKLMLGNEAVARGAYEAGVLVATAYPGTPSTEITEHIVKYPEINSEWSVNEKVALEVAI
GSAIAGARTVVSMKHVGLNVAADPLMTVAYTGINAGLLIIVADDPSMHSSQNEQDTRYYG
MFAKIPVLEPSDSQECKDFVKLGLEISEKFDTPVILRLSTRVSHSQSLVELEEKEKIELK
LYDYNPSKYVSAPANAKKRRIFIEERLNELSNFADSSDINKIEYTNKKIGIITSGVAYNY
AKEAVSDASFLKFGMSYPLPEEKIKEFVQNCDKVYVFEELEPIFEQKIRSIGLNVIGKEI
FPVVGELSSEIIRNALLNESKIVIEKIEGLPQRPPVLCPGCHHRGPFYVLKKLKLHVAGD
IGCYTLGGFEPLNAIDTTICMGASIGMAHGFEMARGKDFAKKSVAVIGDSTFWHSGVTGL
IDIVYNKGHSTVIILDNSITAMTGHQENPSTGKTLSGESTNQIDFEALGRSIGINRIRVV
DAYDLKALEETIKEEVNAEEPSLIITKRPCVLIKGVKFDFKDYKIDPELCTGCKLCLKAG
CPAISFDGKVAKINDSLCVGCGLCKDLCKFSAIVEVVK