Protein Info for MMJJ_RS00430 in Methanococcus maripaludis JJ

Annotation: ribonuclease Z

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 308 TIGR02651: ribonuclease Z" amino acids 2 to 305 (304 residues), 358.9 bits, see alignment E=9.5e-112 PF13691: Lactamase_B_4" amino acids 13 to 68 (56 residues), 36.3 bits, see alignment E=5.2e-13 PF00753: Lactamase_B" amino acids 27 to 81 (55 residues), 37.1 bits, see alignment E=5.1e-13 PF12706: Lactamase_B_2" amino acids 31 to 144 (114 residues), 32.5 bits, see alignment E=1e-11

Best Hits

Swiss-Prot: 94% identical to RNZ_METMP: Ribonuclease Z (rnz) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00784, ribonuclease Z [EC: 3.1.26.11] (inferred from 94% identity to mmp:MMP0906)

Predicted SEED Role

"Ribonuclease Z (EC 3.1.26.11)" in subsystem tRNA processing (EC 3.1.26.11)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.26.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (308 amino acids)

>MMJJ_RS00430 ribonuclease Z (Methanococcus maripaludis JJ)
MKITFLGTGAAIPTKYRAHPSISLKFDGEIFLFDCGENTQRQIIFTDVSPMKINNIFITH
LHGDHVLGLPGLLQSIAFQGRKKTLNIYGPSETAKMIEHIMGVGYHSIDYPINVYEISSK
TPEKIISTNNYEVFSYPVVHSVPALAYVFKQVKKPRMDLEKVKKLGIEIGPDLKRLKDGF
NVELNGKIITPEDVSLPPKKGICVGYSGDTIPLNEFAEFLKELKCNTLIHEATFDKTMER
NAKETLHSTATDALNIAKLSGVSTVLLTHISARYDNIDAFESEIVEFKSENPEIHVLIAE
DLMEYPLK