Protein Info for LRK55_RS18090 in Rhodanobacter denitrificans MT42

Annotation: ribosome biogenesis GTPase Der

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 467 TIGR03594: ribosome-associated GTPase EngA" amino acids 3 to 434 (432 residues), 546.2 bits, see alignment E=9.3e-168 TIGR00231: small GTP-binding protein domain" amino acids 4 to 151 (148 residues), 66.6 bits, see alignment E=3.4e-22 amino acids 178 to 341 (164 residues), 88.8 bits, see alignment E=5e-29 PF01926: MMR_HSR1" amino acids 5 to 119 (115 residues), 96.2 bits, see alignment E=6e-31 amino acids 180 to 298 (119 residues), 100.1 bits, see alignment E=3.9e-32 PF02421: FeoB_N" amino acids 5 to 128 (124 residues), 57.2 bits, see alignment E=6.6e-19 amino acids 180 to 343 (164 residues), 49.5 bits, see alignment E=1.5e-16 PF00009: GTP_EFTU" amino acids 71 to 126 (56 residues), 29.5 bits, see alignment 2.5e-10 amino acids 223 to 346 (124 residues), 37.8 bits, see alignment E=7.2e-13 PF00350: Dynamin_N" amino acids 181 to 224 (44 residues), 27.7 bits, see alignment 1.2e-09 PF14714: KH_dom-like" amino acids 358 to 434 (77 residues), 86.4 bits, see alignment E=5.7e-28

Best Hits

Swiss-Prot: 58% identical to DER_STRMK: GTPase Der (der) from Stenotrophomonas maltophilia (strain K279a)

KEGG orthology group: K03977, GTP-binding protein (inferred from 58% identity to sml:Smlt2060)

Predicted SEED Role

"GTP-binding protein EngA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (467 amino acids)

>LRK55_RS18090 ribosome biogenesis GTPase Der (Rhodanobacter denitrificans MT42)
MLPVVALVGRPNVGKSTLFNVLTRSRDALVADMPGVTRDRHYGICRTGERPFVVVDTGGL
SGIDEAMDVLTARQVRLAIAEADVLVFVVDARDGLLPQDDAILAELRRSGKPIVAAVNKT
DGLDEQAVMAEFFAFGIGATLPLSAAHNRGTDDFLRVLLPLLPADREAAAEAEGEDGSIR
VAIVGRPNAGKSTLINRLLGEERLIVSDVAGTTRDPIRVPLERDGKRYTLIDTAGIRRKA
RVEEAVEKFSVIKTLQSIAAAQVVVVMIDARENLADQDLTLIGYAIDEGRALVIAINKWD
DMDSYQRDECRRALDRRLVFVDWAKQVQISALHGSGLRELMRAVVRAHASATKELVSSDL
TKALEKAYESYQPPLVNGHAPKLRFAHPGGTNPPTIVIHGSRTKHIAPAYQRYLENFFRK
RYKLEGTPIRIVFREGENPYAGRKKVLTKEQQHKARRRLSELIKRTR