Protein Info for LRK55_RS17430 in Rhodanobacter denitrificans MT42

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 transmembrane" amino acids 113 to 134 (22 residues), see Phobius details amino acids 146 to 166 (21 residues), see Phobius details amino acids 178 to 200 (23 residues), see Phobius details amino acids 206 to 224 (19 residues), see Phobius details amino acids 362 to 380 (19 residues), see Phobius details amino acids 386 to 407 (22 residues), see Phobius details amino acids 691 to 712 (22 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 181 to 730 (550 residues), 396.7 bits, see alignment E=2.2e-122 PF00122: E1-E2_ATPase" amino acids 249 to 417 (169 residues), 115.9 bits, see alignment E=2.4e-37 TIGR01494: HAD ATPase, P-type, family IC" amino acids 257 to 707 (451 residues), 182.5 bits, see alignment E=1.1e-57 PF00702: Hydrolase" amino acids 437 to 642 (206 residues), 65.9 bits, see alignment E=1e-21

Best Hits

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (753 amino acids)

>LRK55_RS17430 heavy metal translocating P-type ATPase (Rhodanobacter denitrificans MT42)
MNAYAAWAHPQLAAQVLRVRRDGCSEVALRVEPLNDARQVLWLEQRIRALPGVRRVAIDR
PAQRVRVVWDVQRTSLPSLLDNFAIAGCPAQPLQQDSIDDARAQEQHDALKRLLVAGMCS
MQVMTYAFVIYIGVVDFVDFSTRNLFRWLGLLTSLPVVFYSALPFFRGAVRELGQRRLGI
NLPVALAVALVFLASTFNTLRGSGEIYFDSVTMFVFLLLGGRYVELRSRHHSGALGDAAI
DATPLLAQRRRADGELETVAAIALLSGDRVHVAEGGTVPADGVLESAGAQVDEALLSGES
RPLQRLRGERLVAGSVLLSGPAELRVEHSGATTVAARLGALASRARHARSLIAPSDREVG
RFVARVLVLTALTALGWLLLDPGRAFEAAVAVLVVACPCAFALAGPATLTRALGVLAGRG
VLVTDGKALDTLATVDYALFDKTGTLSVPQLDRRAVEPLRGDTPDRVLQLAAALAHESSH
PLARALADAARQQALSLQAQSVRVHAGAGISGDIDGRELRLGRADFALALAGQTAPSVVT
DTLLLADAQGAIATFHLDEQPRADARRMLDALRADGIAVAIASGDSAPRVATLAARLDIG
DWHARQSPAAKLERLQAAREHGHTTLAVGDGSNDAPLLAGADVSAALASGTELAQAHADL
LLLDGHLGSLADARAIARQSRQLMAQSRRWSLLYNLCAVPFAALGLVPPWLAGIGMSLSS
LAVILNALRVGGDTAAGRSGASGPAARPRELRA