Protein Info for LRK55_RS17395 in Rhodanobacter denitrificans MT42

Annotation: aldehyde dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 17 to 469 (453 residues), 455 bits, E=1.2e-140

Best Hits

KEGG orthology group: None (inferred from 69% identity to psu:Psesu_1344)

Predicted SEED Role

"Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization (EC 1.5.1.12)

MetaCyc Pathways

• L-arginine degradation I (arginase pathway) (3/3 steps found)
• L-proline degradation I (2/3 steps found)
• ethene biosynthesis II (microbes) (1/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glutamate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.5.1.12

Use Curated BLAST to search for 1.5.1.12

Protein Sequence (476 amino acids)

>LRK55_RS17395 aldehyde dehydrogenase family protein (Rhodanobacter denitrificans MT42)
MLNKTYPYYLANRPQTAKTMLEVFDKYSGKLATRVAVPDATATEKAIAAAVKAAKPMREY
KPWARQTVLQYCAARFAERRDELAEALCIEAGKPIKDAAGEVTRLIETFRIAAEEAVRIN
GETINLELASRLDGYHGYTRRVPLGPVSFITPFNFPLNLVAHKVAPAIAAGCPFVLKPSE
KTPIGALIIGEVLAETDLPKGAFSILTLDGAHAAPLVEDPRFKLLSFTGGQVGWALKARA
GHKKVTLELGGNAACIVDADQDGKLDHVVQRLVFGAFYQSGQSCIGVQRIYAHADIYDAL
KRKLVAATKKLKAGDPKDRSVFLGPMIDEAAAERLHGWILEAKQAGGRILCGGKRHGNML
DATLMEDVPADAKANRMEAFGPFALLAPFRRFDEAIAMVNDSDYGLQAGIFTDSLAHAMR
AWNELEQGGVIVNDIPSFRVDNMPYGGVKLSGLGREGVRYAIEDMSETRLMVMRES