Protein Info for LRK55_RS17315 in Rhodanobacter denitrificans MT42

Annotation: cation diffusion facilitator family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 transmembrane" amino acids 18 to 39 (22 residues), see Phobius details amino acids 48 to 67 (20 residues), see Phobius details amino acids 85 to 104 (20 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 153 to 173 (21 residues), see Phobius details amino acids 179 to 199 (21 residues), see Phobius details TIGR01297: cation diffusion facilitator family transporter" amino acids 16 to 290 (275 residues), 285.7 bits, see alignment E=1.9e-89 PF01545: Cation_efflux" amino acids 19 to 209 (191 residues), 151.8 bits, see alignment E=1e-48

Best Hits

Swiss-Prot: 42% identical to ZITB_ECO57: Zinc transporter ZitB (zitB) from Escherichia coli O157:H7

KEGG orthology group: K03295, cation efflux system protein, CDF family (inferred from 64% identity to sml:Smlt1428)

MetaCyc: 42% identical to Zn2+/Cd2+/Ni2+/Cu2+ exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-200

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcD" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (301 amino acids)

>LRK55_RS17315 cation diffusion facilitator family transporter (Rhodanobacter denitrificans MT42)
MNVGHDHVGTKVKHETPLWWALGLTSMFLVAEIIGGLLTNSLALLSDAAHMATDVIALTI
SLTAVRLARRPPDAKRTYGYARMEAIGALVNGGLLFLVASYILWEAVRRFSEPPSVASTG
MLVIAVLGLMINLASMRLLKAGSGESLNVKGAYLEVWADMLGSIGVIVAALIIKFTGFYI
ADPIIAVLIGLWVLPRTWILLREAGNVLMEGAPGGVDTEKVRAEMLATPGVVALHDVHVW
ALSSTRSAMTAHVIMDGDASGAEALRLRLAQMLEASFDIHHVTLQVETTSCGLECEKPQK
V