Protein Info for LRK55_RS14445 in Rhodanobacter denitrificans MT42

Annotation: methionine ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 225 transmembrane" amino acids 25 to 48 (24 residues), see Phobius details amino acids 60 to 84 (25 residues), see Phobius details amino acids 95 to 115 (21 residues), see Phobius details amino acids 153 to 176 (24 residues), see Phobius details amino acids 196 to 215 (20 residues), see Phobius details PF00528: BPD_transp_1" amino acids 39 to 222 (184 residues), 77.9 bits, see alignment E=4.2e-26

Best Hits

Swiss-Prot: 54% identical to METI_ECOLI: D-methionine transport system permease protein MetI (metI) from Escherichia coli (strain K12)

KEGG orthology group: K02072, D-methionine transport system permease protein (inferred from 66% identity to pfl:PFL_4166)

MetaCyc: 54% identical to L-methionine/D-methionine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter permease protein" in subsystem Methionine Biosynthesis or Methionine Degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (225 amino acids)

>LRK55_RS14445 methionine ABC transporter permease (Rhodanobacter denitrificans MT42)
MNPLPKLFPNIDDWGEIGRACIDTLLMLGGSLALTVLIGLPLGVLLYLTGKGQLRPMPKL
YAIASLLVNILRSVPFIILMIVLMPVTYALVGTKLGIRGAIPPLVIGAAPFFARLVETAL
REVQQGVIEASQAMGASLWQIVRHVLLPEARGGLFAGITVTAIALVGYTAMGGAIGSGGL
GDLAYRYGYLSYKSDYMLVTVVLLIVLVQLLQMVGDHIVTRYKQR