Protein Info for LRK55_RS09510 in Rhodanobacter denitrificans MT42

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 431 to 452 (22 residues), see Phobius details amino acids 464 to 487 (24 residues), see Phobius details amino acids 530 to 549 (20 residues), see Phobius details amino acids 861 to 880 (20 residues), see Phobius details amino acids 887 to 907 (21 residues), see Phobius details amino acids 913 to 939 (27 residues), see Phobius details amino acids 960 to 981 (22 residues), see Phobius details amino acids 993 to 1020 (28 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1017 (1014 residues), 993.4 bits, see alignment E=6.1e-303

Best Hits

Swiss-Prot: 44% identical to MDTB_KLEP3: Multidrug resistance protein MdtB (mdtB) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 73% identity to xca:xccb100_3972)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1046 amino acids)

>LRK55_RS09510 efflux RND transporter permease subunit (Rhodanobacter denitrificans MT42)
MNLSGTFIRRPIGTSLLAIGLFVGGMIGYFLLGVAALPNMQFPAIFVQASQAGADASTMA
STVAAPLERHLGQVPGIETMRSSGSEGRTFVFMMFRNGTDLDSAARDVQAAINSAAPDLP
SGLNGAPSYQKANPNDDPIIALALTSATQSAADLYNLSDTLLAQRLRQLPGVSSVEIAGA
ATPAIRVDVNLRALNAMGLSPDQLRNALSAANLTSPEGFLSNGKTTMSISATTQLHSAEE
FAQLVIASRNGTPVRLADVAKVYAGQQDAYQAAWFHGKPAVLMYVYKKADANVIATVDLV
RDQLPLLRDYLPPATVLTPFFDGTPTIRASLHEVQATLLISLAMVILVMALFLRRLAPTL
IAAVAVPLSLAGAFVVMYILGYTLNNLTLLALVIAIGFVVDDAIVVIENIIRHIDAGMSR
MQATLAGAREIGFTIVSITASLIAVFIPLLFAGGVTGMFMHEFSVTLVAAIVVSALVSLT
LTPALCGRFLNGHAAKEKTQPSRRARALDGFHAGMLRVYTRALNFSLRHALLFSLTPLVL
IVVTFYLFGVVKTGLFPAQDTGLIWGRASSSATVSFAESRQRLERLTTMLMADPDVATVG
SRLGSSRQGTSGSFNIDLKTRAEGRQDDTFAVLARLSAKAANYPDLNLRLRPVQDLPSGG
GGGTSQGAQYQVSLQGNDLASLQEWLPKLQTELKKNPKLRDVGTDVDEAGLRQNIVIDRD
KAARLGVSIGAIDGALYDAFGQRQVSTIYSDINQYQVVVNALPEQTATPEALNRIYVRSG
SGRMIPITAFAQQQPGLAPSQITHENQYTTMDLSFNLAPGVSMGEAMAVIQATVKNMRMP
GDIRVQMGNDFRRFQQSQSGMGWLILAAVLTVYIVLGMLYENLIHPITILSTLPAAGVGA
LLALWITGTELSVVAQIALVLLIGIVKKNAIMMIDFALVAQREHGKSPLEAAREACTVRF
RPIMMTTMVAILAALPIAIGLGEGSELRRPLGIALIGGLLISQSLTLLSTPALYVVFSCL
AERRKAWWARRQERRAARRRRQLAEI