Protein Info for LRK55_RS08710 in Rhodanobacter denitrificans MT42

Annotation: phosphomannomutase/phosphoglucomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 317 to 443 (127 residues), 131.5 bits, E=3.7e-42
• PF02879: PGM_PMM_II
  • amino acids 464 to 560 (97 residues), 100.2 bits, E=1.8e-32
• PF02880: PGM_PMM_III
  • amino acids 565 to 675 (111 residues), 77.3 bits, E=2.1e-25
• PF00408: PGM_PMM_IV
  • amino acids 682 to 759 (78 residues), 47.4 bits, E=3.3e-16

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8) / Phosphoglucomutase (EC 5.4.2.2)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.2, EC 5.4.2.8)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (11/11 steps found)
• superpathway of anaerobic sucrose degradation (16/19 steps found)
• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• GDP-mannose biosynthesis (4/4 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
• D-galactose degradation I (Leloir pathway) (2/5 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• sucrose biosynthesis II (4/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (1/4 steps found)
• starch degradation III (1/4 steps found)
• starch degradation V (1/4 steps found)
• glycogen degradation II (2/6 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen degradation I (3/8 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (1/8 steps found)
• starch biosynthesis (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (7/19 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• streptomycin biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Pentose phosphate pathway
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.2

Use Curated BLAST to search for 5.4.2.2 or 5.4.2.8

Protein Sequence (770 amino acids)

>LRK55_RS08710 phosphomannomutase/phosphoglucomutase (Rhodanobacter denitrificans MT42)
MALNIANERLRNLRVDWRDLLPLAGGTALLLLGLFCAWQTWLIADEGNAVRRVHLAQDEA
VRALAAEIASQRGAVEKVLASVDPATLMSDPAQSAAALRRQLPQAKKLELYSGELTEVLK
ANYREFGYAKAAQLMAAQSAEGLPLAQSVSYGNGDRRLSLVIPLGPPQRAQAWAWVELPF
APLRQRFDAISPAGGRLDLRQGDDRGYVQLLSHGTRSAEAEATGKPVAGSVFSVGAGLPG
AFIVLPRWWLLSGLLALLGLGGGGYLLRLRQRWKALPEVEEPEVPLPARQTAPARAKPPE
PPERPAAAPVAGVDPSIFRAYDVRGVVGKTLNKEVARALGQSIGTLMVEKGLREIVVGRD
GRLSGPELAAALADGLREAGVDVIDIGAVPTPVVYYATYRFNTGCGVAVTGSHNPPDYNG
FKIVVGGQTLAEGAIQDLYQRIAGGALASGGGGGLRQVDVAPDYIEKIIADVLAERRLKV
VVDCGNGIPGAIAPQVLEGVGCEVVPLYCDVDGSFPNHHPDPSDPHNLEDLILAVRQTGA
DLGLAFDGDGDRLGVVTRSGEIVYPDRLLMLFARDVLSRQPGATVIYDVKCTSHLKGQIL
DAGGSPLMWRTGHSLIKAKMRETQAELAGEMSGHFFFKERWYGFDDGIYAAARLLEILAG
DLQGRSAEQIFATLPKSVSTPELKVELAEGEHYRFMDQLRQQASFEDASLITIDGVRADW
PDGWGLVRASNTTPVLVLRFEADDPVALKRIQQLFRRQLLAVNPGLKLPF